Category:LBS/Biosynthesis/CeramideSyn: Difference between revisions
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| [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb) | | [http://www.uniprot.org/uniprot/Q8NFR3 SPTSSB] (ssSPTb) | ||
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|rowspan="1"| 3-Ketodihydrosphingosine reductase | |||
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| [http://www.uniprot.org/uniprot/Q06136 KDSR] | | [http://www.uniprot.org/uniprot/Q06136 KDSR] | ||
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Revision as of 01:54, 18 December 2017
Enzyme function in the Human Genome | |||
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Protein name | Gene name (Uniprot) | Location | |
Serine palmitoyl transferase (SPT) | SPTLC1 | A heterodimer membrane protein (LC1-LC2 or LC1-LC3) whose catalytic site faces the cytosol. In addition, small subunits (SPTSSA or SPTSSB) are essential for the full enzymatic activity.
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SPTLC2 | |||
SPTLC3 | |||
SPTSSA (ssSPTa) | |||
SPTSSB (ssSPTb) | |||
3-Ketodihydrosphingosine reductase | |||
KDSR | |||
Ceramide synthase | CerS1 (LAG1 longevity assurance homolog 1) |
19q12 | Brain, skeletal muscle, testis for C18 |
CerS2 (Tumor metastasis-suppressor gene 1) |
1q21.2 | Kidney, liver and other >12 organs for C20-C26 | |
CerS3 | 15q26.3 | Skin, testis for C22-C26 α-hydroxy chains | |
CerS4 | 19q13.2 | Low in all tissues for C18-C22. Esp. skin, leucocytes, heart, liver. | |
CerS5 | 12q13.3 | Low in all tissues for C16. Esp. muscle and brain. Major in lung epithelia. | |
CerS6 | 2q24.3 | Low in all tissues for C14-C16 | |
Dihydroceramide Δ4-desaturase | DEGS1 (DES1) | 1q42.11 | |
DEGS2 (DES2) | The enzyme hydroxylates DES to form phytoceramide. |
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