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LBS/Biosynthesis/Ganglioside
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GlucosylCeramide (GlcCer)
SA ... sialic acid; SAT ... SA transferase
LacCer synthase
LactosylCeramide (LacCer)
SAT I
GM3
SAT II
GD3
SAT III
GT3
+ GalNAc
↓
↓
↓
↓
GA2
GM2
GD2
GT2
+ Gal
↓
↓
↓
↓
GA1
GM1a
GD1b
GT1c
+ SA
↓
↓
↓
↓
cisGM1
GD1a
GT1b
GQ1c
+ SA
↙ ↘
↙ ↘
↙ ↘
↙ ↘
GD1c, 1α
GT1a, 1aα
GQ1b, 1bα
GP1c, 1cα
SA to 2nd Gal
0-Series (0)
a-Series (1)
b-Series (2)
c-Series (3)
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