LBF20406HO11: Difference between revisions

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|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]].
|Metabolism=5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]].
|Symbol=5(S)-HETE
|Biological Activity=5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin I<SUB><FONT SIZE=-1>2</FONT></SUB> and E<SUB><FONT SIZE=-1>2</FONT></SUB> synthesis in histamine or arachidonic acid stimulated human endothelial cells [[Reference:Richards_CF:Johnson_AR:Campbell_WB:,Biochim. Biophys. Acta,1986,875,569|{{RelationTable/GetFirstAuthor|Reference:Richards_CF:Johnson_AR:Campbell_WB:,Biochim. Biophys. Acta,1986,875,569}}]].
}}
}}


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{{Lipid/Footer}}

Revision as of 21:00, 6 January 2010

LipidBank Top
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Fatty acid
(脂肪酸)
Glycerolipid
(グリセロ脂質)
Sphingolipid
(スフィンゴ脂質)
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Upper classes: LB LBF



5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
LBF20406HO11.png
Structural Information
5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
  • 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
5(S)-HETE
Formula C20H32O3
Exact Mass 320.23514489
Average Mass 320.46628
SMILES C(CC=CCC=CCC=CC=C[C@H](CCCC(O)=O)O)CCC
Physicochemical Information
5(S)-HETE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on arachidonic acid.
5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes Powell_WS et al..
5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin I2 and E2 synthesis in histamine or arachidonic acid stimulated human endothelial cells Richards_CF et al..
Spectral Information
Mass Spectra
UV Spectra lmax: 236nm e: 27,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406HO11 See above. Powell_WS et al. 1992
n.a. LBF20406HO11 See above. Richards_CF et al. 1986