LBF20406OX01: Difference between revisions

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{{Metabolite
{{Metabolite
|LipidBank=DFA8156
|LipidBank=DFA8156
|LipidMaps=-
|LipidMaps=LMFA03060011
|SysName=5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid
|SysName=5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid
|Common Name=&&5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid&&
|Common Name=&&5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid&&
|UV Spectra=<FONT FACE="Symbol">l</FONT>max: 279nm <FONT FACE="Symbol">e</FONT>: 22,100
|UV Spectra= lambda max: 279nm epsilon : 22,100
|Source=5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]];>.
|Source=5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]].
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Symbol=5-OxoETE/5-KETE
|Biological Activity=It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM [[Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927}}]]. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils [[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336}}]][[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821}}]].
}}
{{MassbankSpectra|
UT000181
UT000182
UT000183
UT000184
UT000185
UT000186
UT000187
UT000188
UT000189
}}
}}


{{Lipid/Footer}}
{{Lipid/Footer}}

Latest revision as of 00:00, 17 January 2014

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Upper classes: LB LBF



5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid
LBF20406OX01.png
Structural Information
5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid
  • 5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid
5-OxoETE/5-KETE
Formula C20H30O3
Exact Mass 318.21949482599996
Average Mass 318.4504
SMILES C(CC=CCC=CCC=CC=CC(CCCC(O)=O)=O)CCC
Physicochemical Information
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils Powell_WS et al..
It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM Powell_WS et al.. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils OFlaherty_JT et al. OFlaherty_JT et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 279nm ε : 22,100
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406OX01 See above. OFlaherty_JT et al. 1996
n.a. LBF20406OX01 See above. OFlaherty_JT et al. 1996
n.a. LBF20406OX01 See above. Powell_WS et al. 1992
n.a. LBF20406OX01 See above. Powell_WS et al. 1994