LBF20406OX01: Difference between revisions

Latest revision as of 00:00, 17 January 2014

Upper classes: LB LBF

5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid

Structural Information
	5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid
	5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid
	5-OxoETE/5-KETE
Formula	C20H30O3
Exact Mass	318.21949482599996
Average Mass	318.4504
SMILES	`C(CC=CCC=CCC=CC=CC(CCCC(O)=O)=O)CCC`
Physicochemical Information






	5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils Powell_WS et al..


	It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM Powell_WS et al.. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils OFlaherty_JT et al. OFlaherty_JT et al..


Spectral Information
Mass Spectra
UV Spectra	λ max: 279nm ε : 22,100
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References

Biospecies	ID	Compound Name	Reference
n.a.	LBF20406OX01	See above.	OFlaherty_JT et al. 1996
n.a.	LBF20406OX01	See above.	OFlaherty_JT et al. 1996
n.a.	LBF20406OX01	See above.	Powell_WS et al. 1992
n.a.	LBF20406OX01	See above.	Powell_WS et al. 1994

@@ Line 6: / Line 6: @@
 |LipidBank=DFA8156
 |LipidMaps=LMFA03060011
-|SysName=5-Oxo- (6-trans,8-cis,10-cis,14-cis) -icosatetraenoic acid
+|SysName=5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid
 |Common Name=&&5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid&&
 |UV Spectra= lambda max: 279nm  epsilon : 22,100
@@ Line 14: / Line 14: @@
 |Symbol=5-OxoETE/5-KETE
 |Biological Activity=It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM [[Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927}}]]. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils [[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336}}]][[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821}}]].
+}}
+{{MassbankSpectra|
+UT000181
+UT000182
+UT000183
+UT000184
+UT000185
+UT000186
+UT000187
+UT000188
+UT000189
 }}
 {{Lipid/Footer}}