LBF20407HO04: Difference between revisions

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|SysName=8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
|SysName=8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
|Common Name=&&8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid&&
|Common Name=&&8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid&&
|UV Spectra=lambdamax: 269 nm epsilon: 40,000
|UV Spectra= lambda max: 269 nm epsilon : 40,000
|Source=8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893|{{RelationTable/GetFirstAuthor|Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893}}]].
|Source=8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893|{{RelationTable/GetFirstAuthor|Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893}}]].
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Symbol=8(S),15(S)-DiHETE
|Symbol=8(S),15(S)-DiHETE
|Biological Activity=8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED _5 _0  of 1.5 muM but is not chemotactic for neutrophils [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893|{{RelationTable/GetFirstAuthor|Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893}}]]. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain [[Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384|{{RelationTable/GetFirstAuthor|Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384}}]].
|Biological Activity=8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED _5 _0  of 1.5 mu M but is not chemotactic for neutrophils [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893|{{RelationTable/GetFirstAuthor|Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893}}]]. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain [[Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384|{{RelationTable/GetFirstAuthor|Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384}}]].
}}
}}


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Revision as of 14:00, 19 February 2010

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Upper classes: LB LBF



8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
LBF20407HO04.png
Structural Information
8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
  • 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid
8(S),15(S)-DiHETE
Formula C20H32O4
Exact Mass 336.23005951199997
Average Mass 336.46567999999996
SMILES C(CCC(C=CC=CC=CC(CC=CCCCC(O)=O)O)O)CC
Physicochemical Information
8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase Morita_E et al..
8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED _5 _0 of 1.5 mu M but is not chemotactic for neutrophils Morita_E et al.. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain Oliw_EH .
Spectral Information
Mass Spectra
UV Spectra λ max: 269 nm ε : 40,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20407HO04 See above. Morita_E et al. 1990