LBF20407HO04

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Upper classes: LB LBF



(8S,15S) -Dihydroxy- (5Z,9E,11Z,13E) -eicosatetraenoic acid
LBF20407HO04.png
Structural Information
(8S,15S) -Dihydroxy- (cis-5,trans-9,cis-11,trans-13) -eicosatetraenoic acid
  • (8S,15S) -Dihydroxy- (5Z,9E,11Z,13E) -eicosatetraenoic acid
  • 8,15-DiHETE
8(S),15(S)-DiHETE
Formula C20H32O4
Exact Mass 336.23005951199997
Average Mass 336.46567999999996
SMILES C(CCC(C=CC=CC=CC(CC=CCCCC(O)=O)O)O)CC
Physicochemical Information
8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase Morita_E et al..
8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED _{50} of 1.5 μ M but is not chemotactic for neutrophils Morita_E et al.. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain Oliw_EH .
Spectral Information
Mass Spectra
UV Spectra λ max: 269 nm ε : 40,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20407HO04 See above. Morita_E et al. 1990