LBF20406LT03
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | XPR3111 |
| LipidMaps | LMFA03020024 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406LT03 |
| 12-oxo-Leukotriene B4 | |
|---|---|
| |
| Structural Information | |
| 5S-12-Keto- (cis-6,trans-8,trans-10,cis-14) -eicosatetraenoic acid | |
| |
| 12-oxo-LTB4 | |
| Formula | C20H30O4 |
| Exact Mass | 334.21440944799997 |
| Average Mass | 334.4498 |
| SMILES | C(CC=CCC(C=CC=CC=C[C@H](CCCC(O)=O)O)=O)CCC |
| Physicochemical Information | |
| Soluble in ethanol, methanol, ethyl acetate, acetonitril | |
| This metabolite is derived from LTB4 by LTB4 12-hydroxydehydrogenase. LTB4 12-hydroxydehydrogenase is expressed most abunduntly in liver and kidney. | |
| Increase in intracellular calcium in human leukocytes probably through BLT (LTB4 receptor). The IC 50 value is 100 times higher than that of LTB4. | |
| LTB4 12-hydroxydehydrogenase cDNA is cloned from various animals. The accession numbers in DDBJ/EMBL/Genbank are shown in ( ). Pig (D49386) Yokomizo_T et al. Ensor_CM et al. Human (D49387) Yokomizo_T et al. Rat (U66322) Primiano_T et al. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | UV maxima 316 nm, Absorbance at 320 nm is 41000/M |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | 12-oxo-LTB4 is eluted at 7.8 min on RP-HPLC system as follows: Solvent:acetonitril/water/acetic acid, 50:50:0.01 (v/v/v), 0.01 % (w/v) Na2EDTA, pH 5.6 with ammonia Flow: 1 ml/min, isocratic Column: Cosmosil 5C18-AR (4.6 x 150 mm, Nacalai tesque, Tokyo) YokomizoTet al. |
| Reported Metabolites, References | |||||||||||||||||||||||||
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