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==糖鎖==
==Polysaccharide Chain==
 
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!colspan="3"|1st Class
!colspan="3"|1st Class
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|- valign="top"
| Gala (Ga)<br/>
| <big>Gala (Ga)</big><br/>
<br/>
<br/>
Gal#alpha;-4(6)Gal#beta;1-Cer
Gal&alpha;-4(6)'''Gal&beta;1'''-Cer
| Globo (Gb)<br/>
| <big>Globo (Gb)</big><br/>
<br/>
<br/>
Gal#alpha;1-4Gal#beta;1-4Glc#beta;1-Cer
'''Gal&alpha;1-4'''Gal&beta;1-4Glc&beta;1-Cer
| Isoglobo (iG)<br/>
| <big>Isoglobo (iG)</big><br/>
<br/>
<br/>
Gal#alpha;1-3Gal#beta;1-4Glc#beta;1-Cer
'''Gal&alpha;1-3'''Gal&beta;1-4Glc&beta;1-Cer
|-  
|-  
| <big>Lacto (Lc)</big><br/>
<br/>
'''Glc&beta;1-3'''Gal&beta;1-4Glc&beta;1-Cer
| <big>Neolacto (nL)</big><br/>
<br/>
'''Gal&beta;1-4GlcNAc&beta;1-3'''Gal&beta;1-4Glc&beta;1-Cer
|-
| <big>Ganglio (Gg)</big><br/>
<br/>
'''GalNAc&beta;1-4'''Gal&beta;1-4Glc&beta;1-Cer
|-
| <big>Isoganglio (iG)</big><br/>
<br/>
'''GalNAc&beta;1-3'''Gal&beta;1-4Glc&beta;1-Cer
| <big>Lactoganglio (LG)</big><br/>
<br/>
GalNAc&beta;1-4(GlcNAc&beta;1-3)Gal&beta;1-4Glc&beta;1-Cer
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Revision as of 03:50, 22 November 2009

Sphingolipid (スフィンゴ脂質)

Class Overview

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
The Sphingolipid category (LBS) includes glycosphingolipid, phosphosphingolipid, and ceramide.

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。 スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
スフィンゴ脂質カテゴリー (LBS)には、スフィンゴ糖脂質 (glycosphingolipid)、スフィンゴリン脂質 (phosphosphingolipid) 、セラミド (ceramide)が含まれています。

Common Abbreviations よく使う略称

Cer Ceramides セラミド
Sph Sphingosine スフィンゴシン


Design of Sphingolipid Identifiers ID番号の設計

25-DIGIT(5+9+9+2)

L B S a a : x1 x1 y1 z1 z1 w1 w1 c1 c1 : x2 x2 y2 z2 z2 w2 w2 c2 c2

  • a ... the number of attached sugars　(glycosphingolipid) or the code of phosphorylation (PP: phosphosphingolipid)
  • x1 ... carbon chain length (sphingoid base)
  • y1 ... degree of unsaturation (sphingoid base)
  • z1 ... position of n－z (n minus z; also ω－z or omega-z) nomenclature (sphingoid base)
  • w1 ... structure type (sphingoid base)
  • c1 ... serial number (sphingoid base)
  • x2 ... carbon chain length (acyl chain)
  • y2 ... degree of unsaturation (acyl chain)
  • z2 ... position of n－z (n minus z; also ω－z or omega-z) nomenclature (acyl chain)
  • w2 ... structure type (acyl chain)
  • c2 ... serial number (acyl chain)

  • a ... 修飾する糖の個数 (glycosphingolipid) もしくはリン酸化修飾を示す記号 (PP: phosphosphingolipid)
  • x1 ... 炭素鎖長 (スフィンゴイド塩基)
  • y1 ... 不飽和度 (スフィンゴイド塩基)
  • z1 ... n－z (またはω－zやomega-z)　における数 (スフィンゴイド塩基)
  • w1 ... 骨格のタイプ (スフィンゴイド塩基)
  • c1 ... 通し番号 (スフィンゴイド塩基)
  • x2 ... 炭素鎖長 (アシル基)
  • y2 ... 不飽和度 (アシル基)
  • z2 ... n－z (またはω－zやomega-z)　における数(脂肪酸)
  • w2 ... 骨格のタイプ (アシル基)
  • c2 ... 通し番号 (アシル基)


Classification

By the Number of Sugars 糖の個数

For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP.

スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。

Sphingolipid Overview

Glycosphingolipid
スフィンゴ糖脂質: LBSnn
LBSnn.png

Phosphosphingolipid
スフィンゴリン脂質: LBSPP
LBSPP.png

Table 1. Classification by the Number of Sugars
 
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Polysaccharide Chain

Table 1. Polysaccharide Series
1st Class
Gala (Ga)


Galα-4(6)Galβ1-Cer

Globo (Gb)


Galα1-4Galβ1-4Glcβ1-Cer

Isoglobo (iG)


Galα1-3Galβ1-4Glcβ1-Cer

Lacto (Lc)


Glcβ1-3Galβ1-4Glcβ1-Cer

Neolacto (nL)


Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer

Ganglio (Gg)


GalNAcβ1-4Galβ1-4Glcβ1-Cer

Isoganglio (iG)


GalNAcβ1-3Galβ1-4Glcβ1-Cer

Lactoganglio (LG)


GalNAcβ1-4(GlcNAcβ1-3)Galβ1-4Glcβ1-Cer

Subcategories

This category has the following 4 subcategories, out of 4 total.

L

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