LBF17307HO01: Difference between revisions

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|Common Name=&&12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid&&
|Common Name=&&12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid&&
|UV Spectra=<FONT FACE="Symbol">l</FONT>max: 232nm <FONT FACE="Symbol">e</FONT>: 33,400
|UV Spectra=<FONT FACE="Symbol">l</FONT>max: 232nm <FONT FACE="Symbol">e</FONT>: 33,400
|Source=12(S)-HHTrE is produced either enzymatically by thromboxane A2 synthase on thromboxane A2 or by a nonenzymatic, heme-mediated decomposition of PGH [[Reference:Diczfalusy_U:Falardeau_P:Hammarstrom_S:,FEBS Lett.,1977,84,271|{{RelationTable/GetFirstAuthor|Reference:Diczfalusy_U:Falardeau_P:Hammarstrom_S:,FEBS Lett.,1977,84,271}}]];>.
|Source=12(S)-HHTrE is produced either enzymatically by thromboxane A2 synthase on thromboxane A2 or by a nonenzymatic, heme-mediated decomposition of PGH [[Reference:Diczfalusy_U:Falardeau_P:Hammarstrom_S:,FEBS Lett.,1977,84,271|{{RelationTable/GetFirstAuthor|Reference:Diczfalusy_U:Falardeau_P:Hammarstrom_S:,FEBS Lett.,1977,84,271}}]].
|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8<FONT FACE="Symbol">m</FONT>M [[Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268|{{RelationTable/GetFirstAuthor|Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268}}]];>. Porcine kidney 15-hydroxyprostaglandin dehydrogenase converts 12(S)-HHTrE to 12-OxoHTrE [[Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268|{{RelationTable/GetFirstAuthor|Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268}}]];>.
|Metabolism=12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8<FONT FACE="Symbol">m</FONT>M [[Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268|{{RelationTable/GetFirstAuthor|Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268}}]]. Porcine kidney 15-hydroxyprostaglandin dehydrogenase converts 12(S)-HHTrE to 12-OxoHTrE [[Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268|{{RelationTable/GetFirstAuthor|Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268}}]].
}}
}}


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Revision as of 11:55, 25 November 2009

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Upper classes: LB LBF



12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid
LBF17307HO01.png
Structural Information
12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid
  • 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid
Formula C17H28O3
Exact Mass 280.203844762
Average Mass 280.40242
SMILES CCCCCC(O)C=CC=CCC=CCCCC(O)=O
Physicochemical Information
12(S)-HHTrE is produced either enzymatically by thromboxane A2 synthase on thromboxane A2 or by a nonenzymatic, heme-mediated decomposition of PGH Diczfalusy_U et al..
12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8mM Liu_Y et al.. Porcine kidney 15-hydroxyprostaglandin dehydrogenase converts 12(S)-HHTrE to 12-OxoHTrE Liu_Y et al..
Spectral Information
Mass Spectra
UV Spectra lmax: 232nm e: 33,400
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF17307HO01 See above. Diczfalusy_U et al. 1977
n.a. LBF17307HO01 See above. Liu_Y et al. 1985
n.a. LBF17307HO01 See above. Sadowitz_PD et al. 1987