LBF20307HO01

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Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

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Upper classes: LB LBF

IDs and Links
LipidBank	DFA8144
LipidMaps	LMFA03050007
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20307HO01

15S-Hydroxy- (8Z,11Z,13E) -eicosatrienoic acid
Structural Information
Systematic Name	15S-Hydroxy- (8-cis,11-cis,13-trans) -icosatrienoic acid
Common Name	15S-Hydroxy- (8Z,11Z,13E) -eicosatrienoic acid
Symbol	15(S)-HETrE
Formula	C20H34O3
Exact Mass	322.25079495399996
Average Mass	322.48216
SMILES	C(CCC(C=CC=CCC=CCCCCCCC(O)=O)O)CC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source	15(S)-HETrE is a hydroxy fatty acid derived from dihomo- γ -linolenic acid.
Chemical Synthesis
Metabolism
Biological Activity	Compared to a series of hydroxypolyenoic fatty acids, 15(S)-HETrE is a more potent inhibitor of human 5-lipoxygenase from polymorphonuclear leukocytes having an IC_{50} of 4.6 μ M at an arachidonic acid concentration of 5 μ M Petrich_K et al.. In rat basophilic leukemia cell lysates, 15(S)-HETrE inhibits 5-lypoxygenase with an IC_{50} of 77 μ M (arachidonic acid concentration of 60 μ M) Haviv_F et al.. 15(S)-HETrE is 10- to 20-fold less potent than 15(S)-HETE and 15(S)-HpETE under these experimental conditions Haviv_F et al..
Genetic Information
Note
Spectral Information
Mass Spectra
UV Spectra	λ max: 235nm ε : 23,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20307HO01 See above. Haviv_F et al. 1987 n.a. LBF20307HO01 See above. Petrich_K et al. 1996