LBF20406HO11: Difference between revisions
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|SysName=5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid | |SysName=5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid | ||
|Common Name=&&5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid&& | |Common Name=&&5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid&& | ||
|UV Spectra= | |UV Spectra=lambdamax: 236nm epsilon: 27,000 | ||
|Source=5(S)-HETE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on arachidonic acid. | |Source=5(S)-HETE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on arachidonic acid. | ||
|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism=5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]]. | |Metabolism=5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]]. | ||
|Symbol=5(S)-HETE | |Symbol=5(S)-HETE | ||
|Biological Activity=5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin | |Biological Activity=5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin I_2 and E_2 synthesis in histamine or arachidonic acid stimulated human endothelial cells [[Reference:Richards_CF:Johnson_AR:Campbell_WB:,Biochim. Biophys. Acta,1986,875,569|{{RelationTable/GetFirstAuthor|Reference:Richards_CF:Johnson_AR:Campbell_WB:,Biochim. Biophys. Acta,1986,875,569}}]]. | ||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} | ||
Revision as of 14:00, 19 February 2010
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8129 |
| LipidMaps | LMFA03060002 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406HO11 |
| 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid | |
|---|---|
| |
| Structural Information | |
| 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid | |
| |
| 5(S)-HETE | |
| Formula | C20H32O3 |
| Exact Mass | 320.23514489 |
| Average Mass | 320.46628 |
| SMILES | C(CC=CCC=CCC=CC=C[C@H](CCCC(O)=O)O)CCC |
| Physicochemical Information | |
| 5(S)-HETE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on arachidonic acid. | |
| 5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes Powell_WS et al.. | |
| 5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin I_2 and E_2 synthesis in histamine or arachidonic acid stimulated human endothelial cells Richards_CF et al.. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | lambdamax: 236nm ε: 27,000 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | |||||||||||||||
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