LBF20406LT13

LipidBank Top (トップ)

Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

Journals (雑誌一覧)

How to edit (ページの書き方)

Upper classes: LB LBF

IDs and Links
LipidBank	XPR3301
LipidMaps	LMFA03020006
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20406LT13

Leukotriene D4
Structural Information
Systematic Name	5S-Hydroxy-6R-S-cysteinylglycinyl- (7-trans,9-trans,11-cis,14-cis) -eicosatetraenoic acid
Common Name	Leukotriene D4 5S-Hydroxy-6R-S-cysteinylglycinyl- (7E,9E,11Z,14Z) -eicosatetraenoic acid 5 (S) -Hydroxy-6 (R) -S-cysteinylglycinyleicosa-7 (E) ,9 (E) ,11 (Z) ,14 (Z) -tetraenoic acid
Symbol	LTD4
Formula	C25H40N2O6S
Exact Mass	496.260707712
Average Mass	496.66098
SMILES	C(=CC=CC=C[C@@H](SC[C@@H](C(=O)NCC(O)=O)N)[C@H](CCCC(O)=O)O)CC=CCCCCC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility	METHANOL Morris_HR et al.
Source	Leukotriene D4 is produced by basophils, eosinophils and macrophages of various animal species upon various stimulations on the cells Samuelsson_B et al. Hammarstrom_S .
Chemical Synthesis	Cohen_N et al.
Metabolism	gamma -Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid Hammarstrom_S ,
Biological Activity	Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted Samuelsson_B et al. Hammarstrom_S . Leukotriene D4 binds to a receptor with 7 transmembrane domains coupled to Gi alpha /o protein (CysLT1) with an affinity higher by two orders of magnitude than that of leukotriene C4 Lynch_KR et al..
Genetic Information	cDNA for CysLT1 was cloned Lynch_KR et al..
Note
Spectral Information
Mass Spectra	N-ACETYL, 5-TRIMETHYLSILYL ETHER DIMETHYL ESTER derivative ; 638(M+), 623, 607, 548, 508, 405, 404, 315, 314, 274, 273 Morris_HR et al.
UV Spectra	λ MeOH max     = 270( ε 32,000), 280( ε 40,000), 290( ε 31,000)nm Lewis_RA et al.
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20406LT13 See above. Cohen_N et al. 1983 n.a. LBF20406LT13 See above. Hammarstrom_S 1983 n.a. LBF20406LT13 See above. Lewis_RA et al. 1980 n.a. LBF20406LT13 See above. Lynch_KR et al. 1999 n.a. LBF20406LT13 See above. Morris_HR et al. 1980 n.a. LBF20406LT13 See above. Samuelsson_B et al. 1982