LBF20406OX01: Difference between revisions

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|Chemical Synthesis=
|Chemical Synthesis=
|Metabolism=
|Metabolism=
|Symbol=5-OxoETE/5-KETE
|Biological Activity=It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM [[Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927}}]]. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils [[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336}}]][[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821}}]].
}}
}}


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Revision as of 21:00, 6 January 2010

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Upper classes: LB LBF



5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid
LBF20406OX01.png
Structural Information
5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid
  • 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid
5-OxoETE/5-KETE
Formula C20H30O3
Exact Mass 318.21949482599996
Average Mass 318.4504
SMILES C(CC=CCC=CCC=CC=CC(CCCC(O)=O)=O)CCC
Physicochemical Information
5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils Powell_WS et al..
It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM Powell_WS et al.. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils OFlaherty_JT et al. OFlaherty_JT et al..
Spectral Information
Mass Spectra
UV Spectra lmax: 279nm e: 22,100
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20406OX01 See above. OFlaherty_JT et al. 1996
n.a. LBF20406OX01 See above. OFlaherty_JT et al. 1996
n.a. LBF20406OX01 See above. Powell_WS et al. 1992
n.a. LBF20406OX01 See above. Powell_WS et al. 1994