LBF20407HO04: Difference between revisions
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|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism= | |Metabolism= | ||
|Symbol=8(S),15(S)-DiHETE | |||
|Biological Activity=8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED <SUB><FONT SIZE=-1>5</FONT></SUB><SUB><FONT SIZE=-1>0</FONT></SUB> of 1.5 <FONT FACE="Symbol">m</FONT>M but is not chemotactic for neutrophils [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893|{{RelationTable/GetFirstAuthor|Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893}}]]. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain [[Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384|{{RelationTable/GetFirstAuthor|Reference:Oliw_EH:,Biochim. Biophys. Acta,1984,795,384}}]]. | |||
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{{Lipid/Footer}} | {{Lipid/Footer}} | ||
Revision as of 21:00, 6 January 2010
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8105 |
| LipidMaps | - |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20407HO04 |
| 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid | |
|---|---|
| |
| Structural Information | |
| 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid | |
| |
| 8(S),15(S)-DiHETE | |
| Formula | C20H32O4 |
| Exact Mass | 336.23005951199997 |
| Average Mass | 336.46567999999996 |
| SMILES | C(CCC(C=CC=CC=CC(CC=CCCCC(O)=O)O)O)CC |
| Physicochemical Information | |
| 8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase Morita_E et al.. | |
| 8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED 50 of 1.5 mM but is not chemotactic for neutrophils Morita_E et al.. 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain Oliw_EH . | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | lmax: 269 nm e: 40,000 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | ||||||||||
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