Category:LBS/Biosynthesis/GIPC: Difference between revisions

Latest revision as of 23:56, 19 December 2017

palmitoyl (16:0)-CoA
+
serine

SPT

3-keto sphinganine

KSR

sphinganine
d18:0

LCB C-4 OHase

phytosphinganine
t18:0

LCFA-CoA

CS I^[1]

Lumen of endoplasmic
reticulum (ER)

VLCFA-CoA

CS II

Abbreviations
CS I/II	(dihydro)ceramide synthase I/II
DAG	diacylglycerol
DES	desaturase
FA OHase	Fatty-acid hydroxylase
GCS	glucosylceramide synthase
IPCS	inositol phosphoceramide synthase
KSR	3-ketosphinganine reductase
LCB	long-chain base
LCFA	long-chain fatty acid
MT	methyltransferase
PI	phosphatidylinositol
SPT	serine palmitoyltransferase
VLCFA	very long-chain fatty acid

d18:0-LCFA

t18:0-VLCFA

Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)

Δ8 DES
FA-αOHase

Bold font = ceramides

d18:1Δ8E/Z-hLCFA

t18:1Δ8E/Z-hVLCFA

+UDP-Glc

transport

Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA

Golgi

t18:1Δ8E/Z-hVLCFA

PI

IPCS^[2]

DAG

GIPC

↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146
↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304

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[1] CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146

[2] Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304

[1]

[2]

@@ Line 1: / Line 1: @@
-{| style="text-align:center" cellspacing="0"
+{| style="text-align:center;border-spacing:0;border-collapse:collapse;"
-|-
 | style="background:darkseagreen;border-radius: 20px 0px 0px 20px" | palmitoyl (16:0)-CoA<br/>+<br/>serine
 | style="background:darkseagreen" | SPT<br/>[[File:Arrow00r.png]]<br/>
@@ Line 11: / Line 10: @@
 |-
 | colspan="4"|
-| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.PMID 12782146</ref>}}
+| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146</ref>}}
 | rowspan="4" style="background:darkseagreen; font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Lumen of endoplasmic<br/> reticulum (ER)
 | style="background:darkseagreen" | {{Map/ReactionDown|VLCFA-CoA||CS II}}
@@ Line 18: / Line 17: @@
 |colspan="4" rowspan="7"|
 {| class="wikitable"
-|'''Abbreviations'''<br/>SPT: serine palmitoyltransferase<br/>KSR: 3-ketosphinganine reductase<br/>LCB: long-chain base<br/>GCS: glucosylceramide synthase<br/>CS I/II: (dihydro)ceramide synthase I/II<br/>DES: desaturase<br/>FA OHase: Fatty-acid hydroxylase<br/>MT: methyltransferase<br/>LCFA: long-chain fatty acid<br/>VLCFA: very long-chain fatty acid<br/>IPCS: inositol phosphoceramide synthase<br/>PI: phosphatidylinositol<br/>DAG: diacylglycerol
+!colspan="2"|Abbreviations
+|-
+| CS I/II || (dihydro)ceramide synthase I/II
+|-
+| DAG || diacylglycerol
+|-
+| DES || desaturase
+|-
+| FA OHase || Fatty-acid hydroxylase
+|-
+| GCS || glucosylceramide synthase
+|-
+| IPCS || inositol phosphoceramide synthase
+|-
+| KSR || 3-ketosphinganine reductase
+|-
+| LCB || long-chain base
+|-
+| LCFA || long-chain fatty acid
+|-
+| MT || methyltransferase
+|-
+| PI || phosphatidylinositol
+|-
+| SPT || serine palmitoyltransferase
+|-
+| VLCFA || very long-chain fatty acid
 |}
 | style="background:darkseagreen" | '''d18:0-LCFA'''
@@ Line 39: / Line 64: @@
 |colspan="2" rowspan="3" valign="top"| '''Glc-ceramide'''<br/>Glc-d18:2 4E,8E/Z-hLCFA<br/>Glc-d18:1 8E/Z-hLCFA<br/>Glc-t18:1-hVLCFA
 |rowspan="3" style="background:darkturquoise;border-radius: 20px 0px 0px 20px;font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Golgi
-| style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>(in Golgi)
+| style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>
 |-
-| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226 PMID 12941304</ref>}}
+| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304</ref>}}
 |-
-| style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC''' (in Golgi)
+| style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC'''
 |}
 <references/>

Category:LBS/Biosynthesis/GIPC: Difference between revisions

Latest revision as of 23:56, 19 December 2017

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