Category:LBS/Biosynthesis/GIPC: Difference between revisions

Revision as of 07:07, 13 April 2016

palmitoyl (16:0)-CoA
+
serine

SPT

3-keto sphinganine

KSR

sphinganine
d18:0

LCB C-4 OHase

phytosphinganine
t18:0

LCFA-CoA

CS I^[1]

Lumen of endoplasmic reticulum (ER)

VLCFA-CoA

CS II

Abbreviations SPT: serine palmitoyltransferase KSR: 3-ketosphinganine reductase LCB: long-chain base GCS: glucosylceramide synthase CS I/II: (dihydro)ceramide synthase I/II DES: desaturase FA OHase: Fatty-acid hydroxylase MT: methyltransferase LCFA: long-chain fatty acid VLCFA: very long-chain fatty acid IPCS: inositol phosphoceramide synthase PI: phosphatidylinositol DAG: diacylglycerol

d18:0-LCFA

t18:0-VLCFA

Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)

Δ8 DES
FA-αOHase

Bold font = ceramides

d18:1Δ8E/Z-hLCFA

t18:1Δ8E/Z-hVLCFA

+UDP-Glc

transport

Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA

Golgi

t18:1Δ8E/Z-hVLCFA
(in Golgi)

PI

IPCS^[2]

DAG

GIPC (in Golgi)

↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.PMID 12782146
↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226 PMID 12941304

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@@ Line 11: / Line 11: @@
 |-
 | colspan="4"|
-| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.</ref>}}
+| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.PMID 12782146</ref>}}
 | rowspan="4" style="background:darkseagreen; font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Lumen of endoplasmic reticulum (ER)
 | style="background:darkseagreen" | {{Map/ReactionDown|VLCFA-CoA||CS II}}
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 | style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>(in Golgi)
 |-
-| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226</ref>}}
+| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226 PMID 12941304</ref>}}
 |-
 | style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC''' (in Golgi)