Category:LBS/Biosynthesis/GIPC: Difference between revisions

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|-
|-
| colspan="4"|  
| colspan="4"|  
| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.PMID 12782146</ref>}}
| style="background:darkseagreen" | {{Map/ReactionDown|LCFA-CoA||CS I<ref>CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146</ref>}}
| rowspan="4" style="background:darkseagreen; font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Lumen of endoplasmic<br/> reticulum (ER)
| rowspan="4" style="background:darkseagreen; font-weight: 600; text-shadow:black 3px 3px 5px; color: white; font-size: large"| Lumen of endoplasmic<br/> reticulum (ER)
| style="background:darkseagreen" | {{Map/ReactionDown|VLCFA-CoA||CS II}}
| style="background:darkseagreen" | {{Map/ReactionDown|VLCFA-CoA||CS II}}
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| style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>
| style="background:darkturquoise;border-radius: 0px 20px 0px 0px"| '''t18:1&Delta;8E/Z-hVLCFA'''<br/>
|-  
|-  
| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226 PMID 12941304</ref>}}
| style="background:darkturquoise"| {{Map/ReactionDown|PI|DAG|IPCS<ref>Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304</ref>}}
|-
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| style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC'''
| style="background:darkturquoise;border-radius: 0px 0px 20px 0px"| '''GIPC'''

Revision as of 10:53, 2 June 2016

palmitoyl (16:0)-CoA
+
serine 		SPT

 3-keto sphinganine KSR

 sphinganine
d18:0 		LCB C-4 OHase
 phytosphinganine
t18:0
LCFA-CoA
CS I[1]
Lumen of endoplasmic
reticulum (ER)
VLCFA-CoA
CS II
Abbreviations
SPT: serine palmitoyltransferase
KSR: 3-ketosphinganine reductase
LCB: long-chain base
GCS: glucosylceramide synthase
CS I/II: (dihydro)ceramide synthase I/II
DES: desaturase
FA OHase: Fatty-acid hydroxylase
MT: methyltransferase
LCFA: long-chain fatty acid
VLCFA: very long-chain fatty acid
IPCS: inositol phosphoceramide synthase
PI: phosphatidylinositol
DAG: diacylglycerol
d18:0-LCFA t18:0-VLCFA
Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)
Δ8 DES
FA-αOHase
Bold font = ceramides
d18:1Δ8E/Z-hLCFA t18:1Δ8E/Z-hVLCFA
+UDP-Glc +UDP-Glc transport
Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA 		Golgi t18:1Δ8E/Z-hVLCFA
PI
IPCS[2]
DAG
GIPC
  1. ↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146
  2. ↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304

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