Category:LBS/Biosynthesis/GIPC

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palmitoyl (16:0)-CoA
+
serine 		SPT

 3-keto sphinganine KSR

 sphinganine
d18:0 		LCB C-4 OHase
 phytosphinganine
t18:0
LCFA-CoA
CS I[1]
Lumen of endoplasmic
reticulum (ER)
VLCFA-CoA
CS II
Abbreviations
SPT: serine palmitoyltransferase
KSR: 3-ketosphinganine reductase
LCB: long-chain base
GCS: glucosylceramide synthase
CS I/II: (dihydro)ceramide synthase I/II
DES: desaturase
FA OHase: Fatty-acid hydroxylase
MT: methyltransferase
LCFA: long-chain fatty acid
VLCFA: very long-chain fatty acid
IPCS: inositol phosphoceramide synthase
PI: phosphatidylinositol
DAG: diacylglycerol
d18:0-LCFA t18:0-VLCFA
Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)
Δ8 DES
FA-αOHase
Bold font = ceramides
d18:1Δ8E/Z-hLCFA t18:1Δ8E/Z-hVLCFA
+UDP-Glc +UDP-Glc transport
Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA 		Golgi t18:1Δ8E/Z-hVLCFA
PI
IPCS[2]
DAG
GIPC
  1. ↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. (2003) Biochim Biophys Acta 1632:1-15.PMID 12782146
  2. ↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV (2003) Archiv Biochem Biophys 417:219-226 PMID 12941304

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