Category:LBS/Biosynthesis/GIPC

palmitoyl (16:0)-CoA
+
serine

SPT

3-keto sphinganine

KSR

sphinganine
d18:0

LCB C-4 OHase

phytosphinganine
t18:0

LCFA-CoA

CS I^[1]

Lumen of endoplasmic
reticulum (ER)

VLCFA-CoA

CS II

Abbreviations SPT: serine palmitoyltransferase KSR: 3-ketosphinganine reductase LCB: long-chain base GCS: glucosylceramide synthase CS I/II: (dihydro)ceramide synthase I/II DES: desaturase FA OHase: Fatty-acid hydroxylase MT: methyltransferase LCFA: long-chain fatty acid VLCFA: very long-chain fatty acid IPCS: inositol phosphoceramide synthase PI: phosphatidylinositol DAG: diacylglycerol

d18:0-LCFA

t18:0-VLCFA

Δ8 DES
Δ4 DES
FA-αOHase
(C-9 MT in fungi)

Δ8 DES
FA-αOHase

Bold font = ceramides

d18:1Δ8E/Z-hLCFA

t18:1Δ8E/Z-hVLCFA

+UDP-Glc

transport

Glc-ceramide
Glc-d18:2 4E,8E/Z-hLCFA
Glc-d18:1 8E/Z-hLCFA
Glc-t18:1-hVLCFA

Golgi

t18:1Δ8E/Z-hVLCFA

PI

IPCS^[2]

DAG

GIPC

↑ CS can utilize a range of FA-CoAs (C16-24) but not hydroxy-FA-CoAs. See Sperling P, Heinz E. “Plant sphingolipids: structural diversity, biosynthesis, first genes and functions” Biochim Biophys Acta. 2003 10;1632:1-15. PMID 12782146
↑ Activity of IPCS is high in Fabaceae. See Bromley PE, Li YO, Murphy SM, Sumner CM, Lynch DV. “Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes” Arch Biochem Biophys. 2003 15;417:219-26. PMID 12941304

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