Category:LBSG/NeuGc

NeuGc Distribution

NeuGc is consistently suppressed in vertebrate brains.

Neu5Gc Distribution in Vertebrate Tissues [1]
Species Serum Red blood
cell
Submaxillary
gland
Liver Kidney Milk Brain
Human nr nr
Chimpanzee nr + + nr + + + trace
Macaque + + nr nr nr +
Mouse + + + + nr nr trace
Rat + + + + + nr trace
Rabbit trace + nr + nr
Pig nr + + + + + + nr trace
Cow + + + + + nr ++ trace trace
Sheep + + + trace + + + + trace
Elephant African nr nr nr + + nr + nr
Elephant Asian nr nr nr + + nr nr
Dolphin nr nr nr + + + + + trace
Horse + + + trace + nr trace
Chicken
Xenopus nr nr nr nr nr nr

++: major fraction; +: minor fraction; -: absent; trace: present at 0.8-3%; nr: not reported

  1. Davies LRL, Varki A "Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?" Top Curr Chem 366:31-54, 2015 PMID 23471785

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