LBF17307HO01

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Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

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Upper classes: LB LBF

IDs and Links
LipidBank	DFA8145
LipidMaps	-
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF17307HO01

12S -Hydroxy- (5Z,8E,10Z) -heptadecatrienoic acid
Structural Information
Systematic Name	12S-Hydroxy- (5-cis,8-trans,10-cis) -heptadecatrienoic acid
Common Name	12S -Hydroxy- (5Z,8E,10Z) -heptadecatrienoic acid
Symbol	12(S)-HHTrE
Formula	C17H28O3
Exact Mass	280.203844762
Average Mass	280.40242
SMILES	CCCCCC(O)C=CC=CCC=CCCCC(O)=O
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source	12(S)-HHTrE is produced either enzymatically by thromboxane A2 synthase on thromboxane A2 or by a nonenzymatic, heme-mediated decomposition of PGH Diczfalusy_U et al..
Chemical Synthesis
Metabolism	12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8 mu M Liu_Y et al.. Porcine kidney 15-hydroxyprostaglandin dehydrogenase converts 12(S)-HHTrE to 12-OxoHTrE Liu_Y et al..
Biological Activity	At a concentration of 0.5 μ M 12(S)-HHTrE stimulates prostacyclin production in human endothelial cells Sadowitz_PD et al..
Genetic Information
Note
Spectral Information
Mass Spectra
UV Spectra	λ max: 232nm ε : 33,400
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF17307HO01 See above. Diczfalusy_U et al. 1977 n.a. LBF17307HO01 See above. Liu_Y et al. 1985 n.a. LBF17307HO01 See above. Sadowitz_PD et al. 1987