LBF20107PG10: Difference between revisions
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|LipidBank=XPR1736 | |LipidBank=XPR1736 | ||
|LipidMaps=LMFA03010054 | |LipidMaps=LMFA03010054 | ||
|SysName=9- | |SysName=9-Oxo-15S-hydroxy-prosto-trans-13-en-1-oic acid | ||
|Common Name=&&11-deoxy Prostaglandin | |Common Name=&&11-deoxy Prostaglandin E_1&&9-Oxo-15S-hydroxy-prosto-13(E)-en-1-oic acid&& | ||
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|Biological Activity= 11-deoxy Prostaglandin E1 shows spieces and subtype dependent EP agonistic effect. In guinea pig, 11-deoxy Prostaglandin E1 induce bronchodilation and vasodepression. [[Reference:Hall_DW:Jaitly_KD:,Prostaglandins,1976,11,573|{{RelationTable/GetFirstAuthor|Reference:Hall_DW:Jaitly_KD:,Prostaglandins,1976,11,573}}]] 11-deoxy Prostaglandin E1 is reported to increase cAMP release via EP receptors in Jurkat cells. [[Reference:De_Vries_GW:Guarino_P:McLaughlin_A:Chen_J:Andrews_S:Woodward_DF:,Br. J. Pharmacol.,1995,115,1231|{{RelationTable/GetFirstAuthor|Reference:De_Vries_GW:Guarino_P:McLaughlin_A:Chen_J:Andrews_S:Woodward_DF:,Br. J. Pharmacol.,1995,115,1231}}]] The Ki value of each murine EPs is 600 nM (EP1), 45 nM (EP2), 1.1 nM (EP3), 23 nM (EP4) .[[Reference:Kiriyama_M:Ushikubi_F:Kobayashi_T:Hirata_M:Sugimoto_Y:Narumiya_S:,Br. J. Pharmacol.,1997,122,217|{{RelationTable/GetFirstAuthor|Reference:Kiriyama_M:Ushikubi_F:Kobayashi_T:Hirata_M:Sugimoto_Y:Narumiya_S:,Br. J. Pharmacol.,1997,122,217}}]] 11-deoxy Prostaglandin E1, a selective EP2/EP3/EP4 agonist, inhibites IL-1beta-induced IL-6 production in human gingival fibroblast.[[Reference:Noguchi_K:Shitashige_M:Endo_H:Kondo_H:Ishikawa_I:,J. Periodont. Res.,2002,37,29|{{RelationTable/GetFirstAuthor|Reference:Noguchi_K:Shitashige_M:Endo_H:Kondo_H:Ishikawa_I:,J. Periodont. Res.,2002,37,29}}]] 11-deoxy Prostaglandin E1 stimulates K secretion through EP2 receptors at EC50 values of 8.3 nM in guinea pig distal colonic mucosa .[[Reference:Halm_DR:Halm_ST:,Am. J. Physiol. Gastrointest. Liver Physiol.,2001,281,G984|{{RelationTable/GetFirstAuthor|Reference:Halm_DR:Halm_ST:,Am. J. Physiol. Gastrointest. Liver Physiol.,2001,281,G984}}]] | |||
}} | }} | ||
{{Lipid/Footer}} |
Latest revision as of 08:07, 21 October 2010
LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
IDs and Links | |
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LipidBank | XPR1736 |
LipidMaps | LMFA03010054 |
CAS | |
KEGG | {{{KEGG}}} |
KNApSAcK | {{{KNApSAcK}}} |
mol | LBF20107PG10 |
11-deoxy Prostaglandin E1 | |
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Structural Information | |
9-Oxo-15S-hydroxy-prosto-trans-13-en-1-oic acid | |
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Formula | C20H34O4 |
Exact Mass | 338.24570957599997 |
Average Mass | 338.48156 |
SMILES | C(CC[C@@H](O)C=C[C@H]([C@H]1CCCCCCC(O)=O)CCC(=O)1)CC |
Physicochemical Information | |
11-deoxy Prostaglandin E1 shows spieces and subtype dependent EP agonistic effect. In guinea pig, 11-deoxy Prostaglandin E1 induce bronchodilation and vasodepression. Hall_DW et al. 11-deoxy Prostaglandin E1 is reported to increase cAMP release via EP receptors in Jurkat cells. De_Vries_GW et al. The Ki value of each murine EPs is 600 nM (EP1), 45 nM (EP2), 1.1 nM (EP3), 23 nM (EP4) . Kiriyama_M et al. 11-deoxy Prostaglandin E1, a selective EP2/EP3/EP4 agonist, inhibites IL-1beta-induced IL-6 production in human gingival fibroblast. Noguchi_K et al. 11-deoxy Prostaglandin E1 stimulates K secretion through EP2 receptors at EC50 values of 8.3 nM in guinea pig distal colonic mucosa . Halm_DR et al. | |
Spectral Information | |
Mass Spectra | |
UV Spectra | |
IR Spectra | |
NMR Spectra | |
Other Spectra | |
Chromatograms |
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