LBF20107PG20: Difference between revisions

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|LipidBank=XPR1799
|LipidBank=XPR1799
|LipidMaps=LMFA03010128
|LipidMaps=LMFA03010128
|SysName=6R,9a-epoxy-11a,15S-dihydroxy-prost-13E-en-1-oic acid
|SysName=(6R,9alpha) -Epoxy- (11alpha,15S) -dihydroxy-prost-trans-13-en-1-oic acid
|Common Name=&&6a-Prostaglandin I1&&
|Common Name=&&6alpha-Prostaglandin I_1&&(6R,9alpha) -Epoxy- (11alpha,15S) -dihydroxy-prost-13(E)-en-1-oic acid&&
|Source=
|Chemical Synthesis=
|Metabolism=
|Biological Activity=6 alpha -PGI1 is reported to promote cAMP accumulation in human thyroied slices and cells in a concentration dependent manner.[[Reference:Leighton_JK:DeBrunner-Vossbrinck_BA:Kemper_B:,Biochemistry,1984,23,204|{{RelationTable/GetFirstAuthor|Reference:Leighton_JK:DeBrunner-Vossbrinck_BA:Kemper_B:,Biochemistry,1984,23,204}}]] And also exhibits 6 alpha -PGI1 inhibition of ADP-induced platelet aggregation at the IC50 value of 350 ng/ml.[[Reference:Whittle_BJ:Moncada_S:,Adv. Exp. Med. Biol.,1984,164,193|{{RelationTable/GetFirstAuthor|Reference:Whittle_BJ:Moncada_S:,Adv. Exp. Med. Biol.,1984,164,193}}]]
}}
}}
{{Lipid/Footer}}

Latest revision as of 08:15, 21 October 2010

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Upper classes: LB LBF



6α-Prostaglandin I1
LBF20107PG20.png
Structural Information
(6R,9α) -Epoxy- (11α,15S) -dihydroxy-prost-trans-13-en-1-oic acid
  • 6α-Prostaglandin I1
  • (6R,9α) -Epoxy- (11α,15S) -dihydroxy-prost-13(E)-en-1-oic acid
Formula C20H34O5
Exact Mass 354.240624198
Average Mass 354.48096000000004
SMILES C(CC[C@H](O)C=C[C@H]([C@H]12)[C@H](O)C[C@H](O[C@@H](C2)CCCCC(O)=O)1)CC
Physicochemical Information
6 alpha -PGI1 is reported to promote cAMP accumulation in human thyroied slices and cells in a concentration dependent manner. Leighton_JK et al. And also exhibits 6 alpha -PGI1 inhibition of ADP-induced platelet aggregation at the IC50 value of 350 ng/ml. Whittle_BJ et al.
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20107PG20 See above. Leighton_JK et al. 1984
n.a. LBF20107PG20 See above. Whittle_BJ et al. 1984