LBF20207PG26

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Upper classes: LB LBF

IDs and Links
LipidBank	XPR1511
LipidMaps	LMFA03010026
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20207PG26

15-KETOPROSTAGLANDIN F_2α
Structural Information
Systematic Name	7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3-oxo-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid
Common Name	15-KETOPROSTAGLANDIN F_2α 7- [ 3 (R) ,5 (S) -Dihydroxy-2 (R) - (3-oxo-1 (E) -octenyl) cyclopentan-1 (R) -yl ] -5 (Z) -heptenoic acid
Symbol	15-KETO-PGF2a
Formula	C20H32O5
Exact Mass	352.224974134
Average Mass	352.46508
SMILES	C(CCC(=O)C=C[C@H]([C@H]1CC=CCCCC(O)=O)[C@@H](C[C@@H]1O)O)CC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source	15-Keto-prostaglandin F2a is the oxidized product of prostaglandin F2a by 15-hydroxyprostaglandin dehydrogenase, which is present in lung, kidney, placenta and other tissues and catalyzes the NAD- or NADP-dependent dehydrogenation of 15-dydroxyl group Hansen_HS .
Chemical Synthesis
Metabolism	15-Keto-prostaglandin F2a is further metabolized by its D13-reduction, b-oxidation and w oxidation. The ultimate metabolite is 5a,7a-dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, and excreted in urine Granstrom_E et al..
Biological Activity	It is well known that the biological activities of various prostaglandins are reduced upon their dehydrogenation at carbon-15 by the catalysis of 15-hydroxyprostaglandin dehydrogenase Anggard_E .
Genetic Information	cDNA for placental 15-hydroxyprostaglandin dehydrogenase was cloned Ensor_CM et al..
Note
Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20207PG26 See above. Anggard_E 1966 n.a. LBF20207PG26 See above. Ensor_CM et al. 1995 n.a. LBF20207PG26 See above. Granstrom_E et al. 1971 n.a. LBF20207PG26 See above. Hansen_HS 1976