LBF20207PG26

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Fatty acid (脂肪酸)

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Upper classes: LB LBF

IDs and Links
LipidBank	XPR1511
LipidMaps	LMFA03010026
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20207PG26

15-keto Prostaglandin F2α
Structural Information
Systematic Name	7- [ (3R,5S) -Dihydroxy-2R - (3-oxo-trans-1-octenyl)- cyclopentan-1R -yl] -cis-5-heptenoic acid
Common Name	15-keto Prostaglandin F2α 7- [ (3R,5S) -Dihydroxy-2R - (3-oxo-1(E)-octenyl)- cyclopentan-1R -yl ] -5-(Z)-heptenoic acid
Symbol	15-KETO-PGF2α
Formula	C20H32O5
Exact Mass	352.224974134
Average Mass	352.46508
SMILES	C(CCC(=O)C=C[C@H]([C@H]1CC=CCCCC(O)=O)[C@@H](C[C@@H]1O)O)CC
Physicochemical Information
Melting Point
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Optical Rotation
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Solubility
Source	15-Keto-prostaglandin F2 alpha is the oxidized product of prostaglandin F2 alpha by 15-hydroxyprostaglandin dehydrogenase, which is present in lung, kidney, placenta and other tissues and catalyzes the NAD- or NADP-dependent dehydrogenation of 15-dydroxyl group Hansen_HS .
Chemical Synthesis
Metabolism	15-Keto-prostaglandin F2 alpha is further metabolized by its Delta 13-reduction, beta -oxidation and omega oxidation. The ultimate metabolite is 5 alpha ,7 alpha -dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, and excreted in urine Granstrom_E et al..
Biological Activity	It is well known that the biological activities of various prostaglandins are reduced upon their dehydrogenation at carbon-15 by the catalysis of 15-hydroxyprostaglandin dehydrogenase Anggard_E .
Genetic Information	cDNA for placental 15-hydroxyprostaglandin dehydrogenase was cloned Ensor_CM et al..
Note
Spectral Information
Mass Spectra
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Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20207PG26 See above. Anggard_E 1966 n.a. LBF20207PG26 See above. Ensor_CM et al. 1995 n.a. LBF20207PG26 See above. Granstrom_E et al. 1971 n.a. LBF20207PG26 See above. Hansen_HS 1976