LBF20306PG01

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Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

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Upper classes: LB LBF

IDs and Links
LipidBank	XPR1733
LipidMaps	LMFA03010051
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20306PG01

15-deoxy-Δ12.14-Prostaglandin D2
Structural Information
Systematic Name	9α-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
Common Name	15-deoxy-Δ12.14-Prostaglandin D2 9α-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
Symbol
Formula	C20H30O4
Exact Mass	334.21440944799997
Average Mass	334.4498
SMILES	C([C@H]1CC=CCCCC(O)=O)(C(C[C@@H]1O)=O)=CC=CCCCCC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source
Chemical Synthesis
Metabolism	15-deoxy- Delta ^1 ^2 ^. ^1 ^4 -Prostaglandin D2 is formed from Prostaglandin D2 via Delta ^1 ^2 -Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum. Soderstrom_M et al.
Biological Activity	15-deoxy- Delta ^1 ^2 ^. ^1 ^4 -Prostaglandin D2 shows cytotoxity on murine leukemia cell line (IC50 value of 0.3 mu g/ml). Corey_EJ et al. 15-deoxy- Delta ^1 ^2 ^. ^1 ^4 -Prostaglandin D2 is a potent activator of eosinophils, inducing calcium mobilization, actin polymerization, and CD11b expression. Monneret_G et al.
Genetic Information
Note
Spectral Information
Mass Spectra
UV Spectra	λ max=296nm ε 296=18300
IR Spectra
NMR Spectra
Other Spectra
Chromatograms	PGD2 and other metabolites are separated with HPLC. Please reffer following paper. SoderstromMet al.

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20306PG01 See above. Corey_EJ et al. 1974 n.a. LBF20306PG01 See above. Monneret_G et al. 2002 n.a. LBF20306PG01 See above. Soderstrom_M et al. 2003