LBF20306PG01

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Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

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Upper classes: LB LBF

IDs and Links
LipidBank	XPR1733
LipidMaps	LMFA03010051
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20306PG01

15-deoxy-Δ12.14- Prostaglandin D2
Structural Information
Systematic Name	9α-Hydroxy-11-oxo-prosta- (cis-5,trans-12,trans-14) -trien-1-oic acid
Common Name	15-deoxy-Δ12.14- Prostaglandin D2 9α-Hydroxy-11-oxo-prosta- (5Z,12E,14E) -trien-1-oic acid
Symbol
Formula	C20H30O4
Exact Mass	334.21440944799997
Average Mass	334.4498
SMILES	C([C@H]1CC=CCCCC(O)=O)(C(C[C@@H]1O)=O)=CC=CCCCCC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source
Chemical Synthesis
Metabolism	15-deoxy- Delta ^{12.14}-Prostaglandin D2 is formed from Prostaglandin D2 via Delta ^{12}-Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum. Soderstrom_M et al.
Biological Activity	15-deoxy- Delta ^{12.14}-Prostaglandin D2 shows cytotoxity on murine leukemia cell line (IC50 value of 0.3 mu g/ml). Corey_EJ et al. 15-deoxy- Delta ^{12.14}-Prostaglandin D2 is a potent activator of eosinophils, inducing calcium mobilization, actin polymerization, and CD11b expression. Monneret_G et al.
Genetic Information
Note
Spectral Information
Mass Spectra
UV Spectra	λ max=296nm ε 296=18300
IR Spectra
NMR Spectra
Other Spectra
Chromatograms	PGD2 and other metabolites are separated with HPLC. Please reffer following paper. SoderstromMet al.

[hide]Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20306PG01 See above. Corey_EJ et al. 1974 n.a. LBF20306PG01 See above. Monneret_G et al. 2002 n.a. LBF20306PG01 See above. Soderstrom_M et al. 2003