LBF20406AM24: Difference between revisions

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(脂肪酸)

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Upper classes: LB LBF

N-Ethyl-N- (2-hydroxyethyl) -arachidonoylamide

Structural Information
	N-Ethyl-N- (2-hydroxyethyl) - (cis-5,cis-8,cis-11,cis-14) -eicosatetraenoylamine
	N-Ethyl-N- (2-hydroxyethyl) -arachidonoylamide N-Ethyl-N- (2-hydroxyethyl) - (5Z,8Z,11Z,14Z) -eicosatetraenoylamine

Formula	C24H41NO2
Exact Mass	375.313729561
Average Mass	375.58788
SMILES	`N(C(=O)CCCC=CCC=CCC=CCC=CCCCCC)(CCO)CC`
Physicochemical Information
	colorless oil Sheskin_T et al.






	This compound was synthesized from arachidonoyl chloried and 2-(ethylamino)ethanol. Yield 83 %. Sheskin_T et al.

	Binding to the brain cannabinoid receptor (CBl), Ki(nM)>10000 Sheskin_T et al.


Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra	¹H NMR (CDCl3) δ 5.31-5.42 (m, 8H), 3.75 (t, J=4.6 Hz, 2H), 3.51 (t, J=4.6Hz, 2H), 3.34(q, J=7.l Hz, 2H), 3.34 (q, J=7.l Hz, 2H), 2.79-2.86 (m, 6H), 2.35 (t, J=7.8Hz, 2H), 2.04-2.15(m, 4H), 1.64-1.77 (m, 2H), 1.25-1.40 (m, 6H), 1.19 (t, J=7.l Hz, 3H), 0.89 (t, J=7.lHz, 3H). Sheskin_Tet al.
Other Spectra
Chromatograms

Reported Metabolites, References

Biospecies	ID	Compound Name	Reference	Comment
n.a.	LBF20406AM24	See above.	Sheskin_T et al. 1997

@@ Line 6: / Line 6: @@
 |LipidBank=XPR7040
 |LipidMaps=LMFA08020026
-|SysName=N-ethyl -N- (2-hydroxyethyl) arachidonoyl amide
+|SysName=N-Ethyl-N- (2-hydroxyethyl) - (cis-5,cis-8,cis-11,cis-14) -eicosatetraenoylamine
-|Common Name=&&N-ethyl -N- (2-hydroxyethyl) arachidonoyl amide&&
+|Common Name=&&N-Ethyl-N- (2-hydroxyethyl) -arachidonoylamide&&N-Ethyl-N- (2-hydroxyethyl) - (5Z,8Z,11Z,14Z) -eicosatetraenoylamine&&
 |Melting Point=colorless oil [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
-|NMR Spectra=<SUP><FONT SIZE=-1>1</FONT></SUP>H NMR (CDCl3) <FONT FACE="Symbol">d</FONT>5.31-5.42 (m, 8H), 3.75 (t, J=4.6 Hz, 2H), 3.51 (t, J=4.6Hz, 2H), 3.34(q, J=7.l Hz, 2H), 3.34 (q, J=7.l Hz, 2H), 2.79-2.86 (m, 6H), 2.35 (t, J=7.8Hz, 2H), 2.04-2.15(m, 4H), 1.64-1.77 (m, 2H), 1.25-1.40 (m, 6H), 1.19 (t, J=7.l Hz, 3H), 0.89 (t, J=7.lHz, 3H).[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
+|NMR Spectra=^1 H NMR (CDCl3)  delta 5.31-5.42 (m, 8H), 3.75 (t, J=4.6 Hz, 2H), 3.51 (t, J=4.6Hz, 2H), 3.34(q, J=7.l Hz, 2H), 3.34 (q, J=7.l Hz, 2H), 2.79-2.86 (m, 6H), 2.35 (t, J=7.8Hz, 2H), 2.04-2.15(m, 4H), 1.64-1.77 (m, 2H), 1.25-1.40 (m, 6H), 1.19 (t, J=7.l Hz, 3H), 0.89 (t, J=7.lHz, 3H).[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
+|Source=
+|Chemical Synthesis=This compound was synthesized from arachidonoyl chloried and 2-(ethylamino)ethanol. Yield 83 %. [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
+|Metabolism=
+|Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
 }}
 {{Lipid/Footer}}

IDs and Links
LipidBank	XPR7040
LipidMaps	LMFA08020026
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}

mol	LBF20406AM24

LBF20406AM24: Difference between revisions

Latest revision as of 13:45, 21 October 2010

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