LBF20406AM34: Difference between revisions
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|LipidBank=XPR7051 | |LipidBank=XPR7051 | ||
|LipidMaps=LMFA08020037 | |LipidMaps=LMFA08020037 | ||
|SysName=N- ( (S) - (+) -2- | |SysName=N-d-2S-Hydroxypropyl-alpha,alpha-dimethyl- (cis-5,cis-8,cis-11,cis-14) -eicosatetraenoylamine | ||
|Common Name=&&N- (S) - (+) -2-Hydroxypropyl-alpha,alpha-dimethylarachidonoylamide&&N- (S) - (+) -2-Hydroxypropyl-alpha,alpha-dimethyl- (5Z,8Z,11Z,14Z) -eicosatetraenoylamine&& | |||
|Melting Point=colorless oil [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | |Melting Point=colorless oil [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | ||
|NMR Spectra= | |NMR Spectra=^1 H NMR (CDCl3) delta 5.95 (br s, lH), 5.30-5.42 (m, 8H), 3.92-3.96 (m, lH), 3.40-3.50 (m, lH), 3.02-3.23 (m, lH), 2.70-2.95 (m, 7H), 2.20-2.28 (m, lH), 2.00-2.15 (m, 4H), 1.70-1.75 (m, 2H) 1.20-1.52 (series of m, 14H), 0.89 (t, J=6.7Hz, 3H). [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | ||
|Source= | |Source= | ||
|Chemical Synthesis=This compound was synthesized from arachidonic acid and (S)-(+)-l-amino-2-propanol. Yield is 57 %. [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | |Chemical Synthesis=This compound was synthesized from arachidonic acid and (S)-(+)-l-amino-2-propanol. Yield is 57 %. [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | ||
|Metabolism= | |Metabolism= | ||
|Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 46.6±2.2 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]] | |||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} | ||
Latest revision as of 04:48, 21 October 2010
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | XPR7051 |
| LipidMaps | LMFA08020037 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406AM34 |
| N- (S) - (+) -2-Hydroxypropyl-α,α-dimethylarachidonoylamide | |
|---|---|
| |
| Structural Information | |
| N-d-2S-Hydroxypropyl-α,α-dimethyl- (cis-5,cis-8,cis-11,cis-14) -eicosatetraenoylamine | |
| |
| Formula | C25H43NO2 |
| Exact Mass | 389.329379625 |
| Average Mass | 389.61446 |
| SMILES | CC(C)(C(=O)NC[C@H](C)O)CCC=CCC=CCC=CCC=CCCCCC |
| Physicochemical Information | |
| colorless oil Sheskin_T et al. | |
| This compound was synthesized from arachidonic acid and (S)-(+)-l-amino-2-propanol. Yield is 57 %. Sheskin_T et al. | |
| Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 46.6±2.2 Sheskin_T et al. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | |
| IR Spectra | |
| NMR Spectra | 1H NMR (CDCl3) δ 5.95 (br s, lH), 5.30-5.42 (m, 8H), 3.92-3.96 (m, lH), 3.40-3.50 (m, lH), 3.02-3.23 (m, lH), 2.70-2.95 (m, 7H), 2.20-2.28 (m, lH), 2.00-2.15 (m, 4H), 1.70-1.75 (m, 2H) 1.20-1.52 (series of m, 14H), 0.89 (t, J=6.7Hz, 3H). SheskinTet al. |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | ||||||||||
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