LBF20406OX01: Difference between revisions
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{{Metabolite | {{Metabolite | ||
|LipidBank=DFA8156 | |LipidBank=DFA8156 | ||
|LipidMaps= | |LipidMaps=LMFA03060011 | ||
|SysName=5- | |SysName=5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid | ||
|Common Name=&&5- | |Common Name=&&5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid&& | ||
|UV Spectra= | |UV Spectra= lambda max: 279nm epsilon : 22,100 | ||
|Source=5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]] | |Source=5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233}}]]. | ||
|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism= | |Metabolism= | ||
|Symbol=5-OxoETE/5-KETE | |||
|Biological Activity=It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM [[Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927|{{RelationTable/GetFirstAuthor|Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927}}]]. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils [[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel:LW:,J. Immunol.,1996,157,336}}]][[Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821|{{RelationTable/GetFirstAuthor|Reference:OFlaherty_JT:Kuroki_M:Nixon_AB:Wijkander_J:Yee_E:Lee_SL:Smitherman_PK:Wykle_RL:Daniel_LW:,J. Biol. Chem.,1996,271,17821}}]]. | |||
}} | |||
{{MassbankSpectra| | |||
UT000181 | |||
UT000182 | |||
UT000183 | |||
UT000184 | |||
UT000185 | |||
UT000186 | |||
UT000187 | |||
UT000188 | |||
UT000189 | |||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} | ||
Latest revision as of 00:00, 17 January 2014
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8156 |
| LipidMaps | LMFA03060011 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406OX01 |
| 5-Oxo- (6E,8Z,11Z,14Z) -eicosatetraenoic acid | |
|---|---|
| |
| Structural Information | |
| 5-Oxo- (trans-6,cis-8,cis-11,cis-14) -eicosatetraenoic acid | |
| |
| 5-OxoETE/5-KETE | |
| Formula | C20H30O3 |
| Exact Mass | 318.21949482599996 |
| Average Mass | 318.4504 |
| SMILES | C(CC=CCC=CCC=CC=CC(CCCC(O)=O)=O)CCC |
| Physicochemical Information | |
| 5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils Powell_WS et al.. | |
| It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM Powell_WS et al.. 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils OFlaherty_JT et al. OFlaherty_JT et al.. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | λ max: 279nm ε : 22,100 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | |||||||||||||||||||||||||
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