LBF20306EO02: Difference between revisions
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|LipidBank=DFA8111 | |LipidBank=DFA8111 | ||
|LipidMaps=- | |LipidMaps=- | ||
|SysName= | |SysName=dl-8 (9) -Epoxy- (cis-5,cis-11,cis-14) -eicosatrienoic acid | ||
|Common Name=&&(+-) 8 (9) - | |Common Name=&&(+-) -8 (9) -Epoxy- (5Z,11Z,14Z) -eicosatrienoic acid&& | ||
|Source=(±)8(9)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 [[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771|{{RelationTable/GetFirstAuthor|Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771}}]][[Reference:Chacos_N:Falck_JR:Wixtrom_C:Capdevila_J:,Biochem. Biophys. Res. Commun.,1982,104,916|{{RelationTable/GetFirstAuthor|Reference:Chacos_N:Falck_JR:Wixtrom_C:Capdevila_J:,Biochem. Biophys. Res. Commun.,1982,104,916}}]]. (±)8(9)-EpETrE is a major P450 metabolite in the renal cortex [[Reference:Zhang_JY:Prakash_C:Yamashita_K:Blair_IA:,Biochem. Biophys. Res. Commun.,1992,183,138|{{RelationTable/GetFirstAuthor|Reference:Zhang_JY:Prakash_C:Yamashita_K:Blair_IA:,Biochem. Biophys. Res. Commun.,1992,183,138}}]]. | |Source=(±)8(9)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 [[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771|{{RelationTable/GetFirstAuthor|Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771}}]][[Reference:Chacos_N:Falck_JR:Wixtrom_C:Capdevila_J:,Biochem. Biophys. Res. Commun.,1982,104,916|{{RelationTable/GetFirstAuthor|Reference:Chacos_N:Falck_JR:Wixtrom_C:Capdevila_J:,Biochem. Biophys. Res. Commun.,1982,104,916}}]]. (±)8(9)-EpETrE is a major P450 metabolite in the renal cortex [[Reference:Zhang_JY:Prakash_C:Yamashita_K:Blair_IA:,Biochem. Biophys. Res. Commun.,1992,183,138|{{RelationTable/GetFirstAuthor|Reference:Zhang_JY:Prakash_C:Yamashita_K:Blair_IA:,Biochem. Biophys. Res. Commun.,1992,183,138}}]]. | ||
|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism= | |Metabolism= | ||
|Symbol=( | |Symbol=(+-)8(9)-EpETrE | ||
|Biological Activity=(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction [[Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578|{{RelationTable/GetFirstAuthor|Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578}}]]>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^2 | |Biological Activity=(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction [[Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578|{{RelationTable/GetFirstAuthor|Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578}}]]>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^{2+} pools in cultured smooth muscle cells [[Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546|{{RelationTable/GetFirstAuthor|Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546}}]]. | ||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} |
Latest revision as of 06:15, 21 October 2010
LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
IDs and Links | |
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LipidBank | DFA8111 |
LipidMaps | - |
CAS | |
KEGG | {{{KEGG}}} |
KNApSAcK | {{{KNApSAcK}}} |
mol | LBF20306EO02 |
(+-) -8 (9) -Epoxy- (5Z,11Z,14Z) -eicosatrienoic acid | |
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Structural Information | |
dl-8 (9) -Epoxy- (cis-5,cis-11,cis-14) -eicosatrienoic acid | |
| |
(+-)8(9)-EpETrE | |
Formula | C20H32O3 |
Exact Mass | 320.23514489 |
Average Mass | 320.46628 |
SMILES | C(CC=CCC=CCC(O1)C1CC=CCCCC(O)=O)CCC |
Physicochemical Information | |
(±)8(9)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 Oliw_EH et al. Chacos_N et al.. (±)8(9)-EpETrE is a major P450 metabolite in the renal cortex Zhang_JY et al.. | |
(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction Katoh_T et al.>.(±)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca^{2+} pools in cultured smooth muscle cells Graber_MN et al.. | |
Spectral Information | |
Mass Spectra | |
UV Spectra | |
IR Spectra | |
NMR Spectra | |
Other Spectra | |
Chromatograms |
Reported Metabolites, References | ||||||||||||||||||||||||||||||
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