LBF20406HO13

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Fatty acid (脂肪酸)

Glycerolipid (グリセロ脂質)

Sphingolipid (スフィンゴ脂質)

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Upper classes: LB LBF

IDs and Links
LipidBank	DFA8131
LipidMaps	LMFA03060006
CAS
KEGG	{{{KEGG}}}
KNApSAcK	{{{KNApSAcK}}}
mol	LBF20406HO13

8S-Hydroxy- (5Z,9E,11Z,14Z) -eicosatetraenoic acid
Structural Information
Systematic Name	8S-Hydroxy- (cis-5,trans-9,cis-11,cis-14) -eicosatetraenoic acid
Common Name	8S-Hydroxy- (5Z,9E,11Z,14Z) -eicosatetraenoic acid
Symbol	8(S)-HETE
Formula	C20H32O3
Exact Mass	320.23514489
Average Mass	320.46628
SMILES	C(CC=CCC=CC=C[C@H](CC=CCCCC(O)=O)O)CCC
Physicochemical Information
Melting Point
Boiling Point
Density
Optical Rotation
Refractive Index
Solubility
Source	8(S)-HETE is a major lipoxygenase product in PMA-treated mouse epidermis Hughes_MA et al..
Chemical Synthesis
Metabolism	8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin Hughes_MA et al..
Biological Activity	Both 8(S)- and 8(R)-HETEs activate mouse skin protein kinase C at a dose of 100 μ M Hughes_MA et al.. It activates mouse keratinocyte protein kinase C with an IC_{50} of 100 mu M Lo_HH et al.. 8(S)-HETE also activates PPAR α selectively at concentrations as low as 0.3 μ M Yu_K et al..
Genetic Information
Note
Spectral Information
Mass Spectra
UV Spectra	λ max: 237nm ε : 27,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References
Biospecies ID Compound Name Reference Comment n.a. LBF20406HO13 See above. Hughes_MA et al. 1991 n.a. LBF20406HO13 See above. Lo_HH et al. 1994 n.a. LBF20406HO13 See above. Yu_K et al. 1995