LBF20406LT04: Difference between revisions
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|LipidBank=XPR3113 | |LipidBank=XPR3113 | ||
|LipidMaps=LMFA03020011 | |LipidMaps=LMFA03020011 | ||
|SysName=N,N- | |SysName=N,N-Dimethyl- (5S,12R) -dihydroxy- (cis-6,trans-8,trans-10,cis-14) -eicosatetraenamide | ||
|Common Name=&& | |Common Name=&&Leukotriene B_4 dimethylamide&&N,N-Dimethyl- (5S,12R) -dihydroxy- (6Z,8E,10E,14Z) -eicosatetraenamide&& | ||
|Source= | |||
|Chemical Synthesis= | |||
|Metabolism= | |||
|Biological Activity=Leukotriene B4 dimethylamide inhibits LTB4 induced degranulation of human neutrophils at the concentration of 130 nM (Ki) and release of lysozyme of PMNL.[[Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565|{{RelationTable/GetFirstAuthor|Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565}}]][[Reference:Shimazaki_T:Kobayashi_Y:Sato_F:Iwama_T:Shikada_K:,Prostaglandins,1990,39,459|{{RelationTable/GetFirstAuthor|Reference:Shimazaki_T:Kobayashi_Y:Sato_F:Iwama_T:Shikada_K:,Prostaglandins,1990,39,459}}]][[Reference:Showell_HJ:Otterness_IG:Marfat_A:Corey_EJ:,Biochem. Biophys. Res. Commun.,1982,106,741|{{RelationTable/GetFirstAuthor|Reference:Showell_HJ:Otterness_IG:Marfat_A:Corey_EJ:,Biochem. Biophys. Res. Commun.,1982,106,741}}]] The effect may be due to the antagonistic effect against LTB4 receptor.[[Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565|{{RelationTable/GetFirstAuthor|Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565}}]] | |||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} |
Latest revision as of 06:23, 9 November 2010
LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
IDs and Links | |
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LipidBank | XPR3113 |
LipidMaps | LMFA03020011 |
CAS | |
KEGG | {{{KEGG}}} |
KNApSAcK | {{{KNApSAcK}}} |
mol | LBF20406LT04 |
Leukotriene B4dimethylamide | |
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Structural Information | |
N,N-Dimethyl- (5S,12R) -dihydroxy- (cis-6,trans-8,trans-10,cis-14) -eicosatetraenamide | |
| |
Formula | C22H37NO3 |
Exact Mass | 363.27734405499996 |
Average Mass | 363.53412000000003 |
SMILES | C(=CC[C@@H](O)C=CC=CC=C[C@H](CCCC(N(C)C)=O)O)CCCCC |
Physicochemical Information | |
Leukotriene B4 dimethylamide inhibits LTB4 induced degranulation of human neutrophils at the concentration of 130 nM (Ki) and release of lysozyme of PMNL. Falcone_RC et al. Shimazaki_T et al. Showell_HJ et al. The effect may be due to the antagonistic effect against LTB4 receptor. Falcone_RC et al. | |
Spectral Information | |
Mass Spectra | |
UV Spectra | |
IR Spectra | |
NMR Spectra | |
Other Spectra | |
Chromatograms |
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