Category:LBS: Difference between revisions
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==Polysaccharide Chain==
==Polysaccharide Chain==
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|+ Table 1. Glycosphingolipids and Phosphosphingolipids  
|+ Table 1. Glycosphingolipids and Phosphosphingolipids  
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| <big>Isoglobo (iG)</big><br/> Gal&alpha;'''1-3''' BASE
| <big>Isoglobo (iG)</big><br/> Gal&alpha;'''1-3''' BASE
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| ...-GlcNac&beta;1-6GalNAc&beta;1-3
| ...-GlcNac&beta;1-6GalNAc&beta;1-3
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| <big>Lactoganglio (LG)</big><br/>
| <big>Lactoganglio (LG)</big><br/>
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|-
<tr><td>
|GalNAc&beta;'''<sup>1</sup>＼<sub>4</sub>'''<br/>
GalNAc&beta;'''<sup>1</sup>＼<sub>4</sub>'''<br/>
GlcNAc&beta;'''<sub>1</sub>／<sup>3</sup>'''
GlcNAc&beta;'''<sub>1</sub>／<sup>3</sup>'''
| BASE
<td> BASE
|}
</tr></table>
| <big>Lacto (Lc)</big><br/> Glc&beta;'''1-3''' BASE
| <big>Lacto (Lc)</big><br/> Glc&beta;'''1-3''' BASE
|-
|-

Revision as of 14:01, 22 November 2009

Sphingolipid (スフィンゴ脂質)

Class Overview

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
The Sphingolipid category (LBS) includes glycosphingolipid, phosphosphingolipid, and ceramide.

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。 スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
スフィンゴ脂質カテゴリー (LBS)には、スフィンゴ糖脂質 (glycosphingolipid)、スフィンゴリン脂質 (phosphosphingolipid) 、セラミド (ceramide)が含まれています。

Common Abbreviations よく使う略称

Cer Ceramides セラミド
Sph Sphingosine スフィンゴシン


Design of Sphingolipid Identifiers ID番号の設計

25-DIGIT(5+9+9+2)

L B S a a : x1 x1 y1 z1 z1 w1 w1 c1 c1 : x2 x2 y2 z2 z2 w2 w2 c2 c2

  • a ... the number of attached sugars　(glycosphingolipid) or the code of phosphorylation (PP: phosphosphingolipid)
  • x1 ... carbon chain length (sphingoid base)
  • y1 ... degree of unsaturation (sphingoid base)
  • z1 ... position of n－z (n minus z; also ω－z or omega-z) nomenclature (sphingoid base)
  • w1 ... structure type (sphingoid base)
  • c1 ... serial number (sphingoid base)
  • x2 ... carbon chain length (acyl chain)
  • y2 ... degree of unsaturation (acyl chain)
  • z2 ... position of n－z (n minus z; also ω－z or omega-z) nomenclature (acyl chain)
  • w2 ... structure type (acyl chain)
  • c2 ... serial number (acyl chain)

  • a ... 修飾する糖の個数 (glycosphingolipid) もしくはリン酸化修飾を示す記号 (PP: phosphosphingolipid)
  • x1 ... 炭素鎖長 (スフィンゴイド塩基)
  • y1 ... 不飽和度 (スフィンゴイド塩基)
  • z1 ... n－z (またはω－zやomega-z)　における数 (スフィンゴイド塩基)
  • w1 ... 骨格のタイプ (スフィンゴイド塩基)
  • c1 ... 通し番号 (スフィンゴイド塩基)
  • x2 ... 炭素鎖長 (アシル基)
  • y2 ... 不飽和度 (アシル基)
  • z2 ... n－z (またはω－zやomega-z)　における数(脂肪酸)
  • w2 ... 骨格のタイプ (アシル基)
  • c2 ... 通し番号 (アシル基)


Classification

By the Number of Sugars 糖の個数

For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP.

スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。

Sphingolipid Overview

Glycosphingolipid
スフィンゴ糖脂質: LBSnn
LBSnn.png

Phosphosphingolipid
スフィンゴリン脂質: LBSPP
LBSPP.png

Table 1. Classification by the Number of Sugars
 
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Polysaccharide Chain

Table 1. Glycosphingolipids and Phosphosphingolipids

Glycosphingolipids (Abbr. BASE = Galβ1-4Glcβ1-Cer)

Gala (Ga)
Galα-4(6)Galβ1-Cer 		Globo (Gb)
Galα1-4 BASE 		Isoglobo (iG)
Galα1-3 BASE
Ganglio (Gg)
GalNAcβ1-4 BASE 		Isoganglio (iG)
GalNAcβ1-3 BASE
Lactoganglio (LG)

GalNAcβ1＼4
GlcNAcβ1／3

BASE
Lacto (Lc)
Glcβ1-3 BASE
Neolacto (nL)
Galβ1-4GlcNAcβ1-3 BASE

Subcategories

This category has the following 4 subcategories, out of 4 total.

L

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