Category:LBS: Difference between revisions

← Older editNewer edit →
Editor (talk | contribs)
editors
12,527 edits
Editor (talk | contribs)
editors
12,527 edits
Line 221: Line 221:
==Polysaccharide Chain==
==Polysaccharide Chain==


<center>
{| class="wikitable"
{| border="1" cellpadding="0" cellspacing="0" style="text-align:right;"
|+ Table 1. Common Categories
|+ Table 1. Glycosphingolipids and Phosphosphingolipids
|-
|-
! style="background:#efefef; text-align:center;" colspan="4"|
! Common Name || Sequence || LipidBank ID
Glycosphingolipids (Abbr. Z = {{LBS/FormatSugar|Galb1-4Glcb1-Cer}})
|- valign="top"
| <big>'''Ganglio''' [Gg] (??)</big><br/> GalNAc&beta;1-4R
| <big>'''Lacto'''  [Lc] (??)</big><br/> GlcNAc&beta;1-3R
| <big>'''Globo'''  [Gb] (??)</big><br/> Gal&alpha;1-4R
| <big>'''Root'''    [R] (??)</big><br/> derivatives of R
|-
|-
| style="vertical-align:top;" |<!---Ganglio--->
|colspan="3" style="background:#efefef; text-align:center"| By GalCer Synthase (EC 2.4.1.62)
{| class="collapsible" border="0" cellspacing="0"
{{#repeat:LBS/AbbrevTable/Row|1|
! style="background:#efefef; text-align:center;" | 3rd saccharide
Gala Gala1-4Galb1-Cer LBS.A2
Spirometo Galb1-4Glcb1-3Galb1-Cer LBS.AG5
}}
|-
|-
|  
|colspan="3" style="background:#efefef; text-align:center"| By GlcCer Synthase (EC 2.4.1.80)
{{#repeat:LBS/AbbrevTable/Row|1|
Ganglio GalNAcb1-4Galb1-4Glcb1-Cer LBS.Z8
Isoganglio GalNAcb1-3Galb1-4Glcb1-Cer LBS.Z7
Globo Gala1-4Galb1-4Glcb1-Cer LBS.Z2
Isoglobo Gala1-3Galb1-4Glcb1-Cer LBS.Z1
Lacto Galb1-3GlcNAcb1-3Galb1-4Glcb1-Cer LBS.ZDE
NeoLacto Galb1-4GlcNAcb1-3Galb1-4Glcb1-Cer LBS.ZDF
Muco Galb1-4Galb1-4Glcb1-Cer LBS.Z5
}}
|-
|-
|  
|colspan="3" style="background:#efefef; text-align:center"| With Mannose
{{#repeat:LBS/AbbrevTable/Row|1|
Arthro GlcNAcb1-3Manb1-4Glcb1-Cer LBS.Y
Mollu Mana1-3Manb1-4Glcb1-Cer LBS.GMM
}}
|}
|}
| style="vertical-align:top;" |<!---Lacto--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 3rd saccharide
|-
| Lacto? ''GlcNAc&beta;1-3'' R
|-
| Lacto Gal&beta;1-3''GlcNAc&beta;1-3'' R
|-
| Neolacto Gal&beta;1-4''GlcNAc&beta;1-3'' R
|}
| style="vertical-align:top;" |<!---Globo--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 3rd saccharide
|-
| [Gal&alpha;1-3]<sub>n</sub> ''Gal&alpha;1-4'' R
|-
| Gal&beta;1-3GalNAc&beta;1-3 ''Gal&alpha;1-4'' R
|-
| GlcNAc&beta;1-6GalNAc&beta;1-3 ''Gal&alpha;1-4'' R
|-
| GalNAc&beta;1-3 ''Gal&alpha;1-4'' R
|}
| style="vertical-align:top;" rowspan="3"|<!---Root--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | structure
|-
| hemato SAs (GM3,GD3,GT3)
|}
|-
| <big>'''Isoganglio''' [IG] (??)</big><br/> GalNAc&beta;1-3R
| <big>Lacto with &beta;1-6 [L6] (??)</big><br/> GlcNAc&beta;1-6R
| <big>'''Isoglobo''' [IB] (??)</big><br/> Gal&alpha;1-3R
|- style="vertical-align:top;"
| <big></big><br/>
{| style="float:right;"
|
|}
| <big>'''Lactoganglio''' [LG]</big><br/>
{| style="float:right;"
|-
|
GalNAc&beta;1-4<br/>
GlcNAc&beta;1-3
| R
|}
| <big>'''Isogloboganglio''' [BG]</big><br/>
{| style="float:right;"
|-
|
GalNAc&beta;1-4<br/>
Gal&alpha;1-3
| R
|}
|}
</center>
<center>
{| border="1" cellpadding="0" cellspacing="0" style="text-align:right;"
|+ Table 1. Glycosphingolipids and Phosphosphingolipids
|-
! style="background:#efefef; text-align:center;" colspan="4"|
Glycosphingolipids without ROOT
|- valign="top"
| <big>'''Glc-Cer''' (??)</big><br/> Glc&beta;1-Cer
| <big>'''Gal-Cer''' (??)</big><br/> Gal&beta;1-Cer
|-
| style="vertical-align:top;" |<!---Glc type--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 2nd saccharide
|-
| Glc-Cer ''Glc&beta;1-Cer''
|-
| Arthro GlcNAc&beta;1-3Man&beta;1-4''Glc&beta;1-Cer''
|-
| Mollu Man&alpha;1-3Man&beta;1-4''Glc&beta;1-Cer''
|-
| Muco Gal&beta;1-4Gal&beta;1-4''Glc&beta;1-Cer''
|-
|
|}
| style="vertical-align:top;" |<!---Gala--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 2nd saccharide
|-
| Gala Gal&alpha;1-4(6)''Gal&beta;1-Cer''
|-
| ??? Gal&beta;1-4(6)''Gal&beta;1-Cer''
|-
| Spirometo Gal&beta;1-4Glc&beta;1-3''Gal&beta;1-Cer''
|-
| NeuAc&alpha;2-3''Gal&beta;1-Cer''
|}
|-
| <big>'''Phospho''' (??)</big><br/> Ino-P-Cer
| <big>'''Others''' (??) </big>
|-
| style="vertical-align:top;" |<!---Phospho--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 2nd saccharide
|
|}
| style="vertical-align:top;" |<!---Others--->
{| class="collapsible" border="0" cellspacing="0"
! style="background:#efefef; text-align:center;" | 2nd saccharide
|-
| ''
|-
|
|}
|}
</center>

Revision as of 21:23, 19 March 2011

Sphingolipid

Class Overview

Sphingosine & Ceramide

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
The Sphingolipid category (LBS) in this database includes glycosphingolipid, phosphosphingolipid, and ceramide.

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。 スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
このデータベースにおけるスフィンゴ脂質カテゴリー (LBS) には、スフィンゴ糖脂質 (glycosphingolipid)、スフィンゴリン脂質 (phosphosphingolipid) 、セラミド (ceramide) が含まれています。

Abbreviations

Design of Page Titles for Sphingolipid

L B S V/I s1 s2 s3 n1 n2 y c1 c2

  • V for vertebrates and I for invertebrates
  • s1 ∼ s3 ... Structure code
The 1st letter s1:
Z for Galβ1-4Glcβ1-1bCer
Y (Arthro) for GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
For others, 0 ∼ Q of the 1st sugar
The 2nd and 3rd letters s2 and s3:
0 to Q for the 3rd and 4th sugars for Z class
0 to Q for the 4th and 5th sugars for Y class
0 to Q for the 2nd and 3rd sugars for others
  • n1, n2 ... the number of sugars
  • y ... the number of sialic acids
  • c1, c2 ... serial numbers

  • x ... 脊椎動物は V 無脊椎動物は I
  • s1 ∼ s3 ... 構造コード
最初の文字 s1:
Z は Galβ1-4Glcβ1-1bCer
Y (Arthro型) は GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
それ以外は最初の糖タイプにより 0 ∼ Q
２番目、３番目の文字 s2 and s3:
Zクラスの場合、３,４番目の糖タイプにより 0 to Q
Yクラスの場合、４,５番目の糖タイプにより 0 to Q
それ以外の場合、２,３番目の糖タイプにより 0 to Q
  • n1, n2 ... 糖の数
  • y ... シアル酸の数
  • c1, c2 ... 通し番号

Sugar Code

"I" and "O" are not used to avoid confusion with "1" or "0".

code sugar code sugar code sugar
0 no sugar A other Galactose (Gal)
including methylation 		L Rhamnose (Rha) or pentose sugars (Ara, Xyl)
1 Galα1-3 B Other N-acetyl galactosamine (GalNAc) or
glucosamine (GlcNAc) 		M Mannose (Man)
2 Galα1-4 C Galactosamine (GalN) or
Glucosamine (GlcN) 		N Neuraminic acids (NeuAc, NeuGc, NeuNH, KDN)
3 Galα1-6 D GlcNAcβ1-3 P phosphocholine (PC), phosphate (HPO3), sulphate (HSO3), and ethylene (2C=CH)
4 Galβ1-3 E GlcNAcβ1-4 Q Aminoethylphosphate (AEPn, MAEPr, EtnP)
5 Galβ1-4 F GlcNAcβ1-6
6 Galβ1-6 G Other Glucose (Glc)
7 GalNAcβ1-3 H Glucuronic acid (GlcA)
8 GalNAcβ1-4 J Inositol (Ins) Y GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
9 GalNAcβ1-6 K Fucose (Fuc) Z Galβ1-4Glcβ1-1bCer

Classification

By the Number of Sugars 糖の個数

For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP.

スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。

Sphingolipid Overview

Glycosphingolipid
スフィンゴ糖脂質: LBSnn

Phosphosphingolipid
スフィンゴリン脂質: LBSPP

Table 1. Classification by the Number of Sugars
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)
 
(0 pages) 		 
(0 pages) 		 
(0 pages) 		 
(0 pages)

Polysaccharide Chain

Table 1. Common Categories
Common Name Sequence LipidBank ID
By GalCer Synthase (EC 2.4.1.62)
Gala 0 Galα1-4Galβ1-Cer
Spirometo 0 Galβ1-4Glcβ1-3Galβ1-Cer
By GlcCer Synthase (EC 2.4.1.80)
Ganglio 0 GalNAcβ1-4Galβ1-4Glcβ1-Cer
Isoganglio 0 GalNAcβ1-3Galβ1-4Glcβ1-Cer
Globo 0 Galα1-4Galβ1-4Glcβ1-Cer
Isoglobo 0 Galα1-3Galβ1-4Glcβ1-Cer
Lacto 0 Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ1-Cer
NeoLacto 0 Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer
Muco 0 Galβ1-4Galβ1-4Glcβ1-Cer
With Mannose
Arthro 0 GlcNAcβ1-3Manβ1-4Glcβ1-Cer
Mollu 0 Manα1-3Manβ1-4Glcβ1-Cer

Subcategories

This category has the following 4 subcategories, out of 4 total.

L

Retrieved from "http://lipidbank.jp/mediawiki/index.php?title=Category:LBS&oldid=21117"