LBF20307HO01: Difference between revisions

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|Metabolism=
|Metabolism=
|Symbol=15(S)-HETrE
|Symbol=15(S)-HETrE
|Biological Activity=Compared to a series of hydroxypolyenoic fatty acids, 15(S)-HETrE is a more potent inhibitor of human 5-lipoxygenase from polymorphonuclear leukocytes having an IC_{50} of 4.6 mu M at an arachidonic acid concentration of 5  mu M [[Reference:Petrich_K:Ludwig_P:Kuhn_H:Schewe_T:,Biochem. J.,1996,314 (Pt 3),911|{{RelationTable/GetFirstAuthor|Reference:Petrich_K:Ludwig_P:Kuhn_H:Schewe_T:,Biochem. J.,1996,314 (Pt 3),911}}]]. In rat basophilic leukemia cell lysates, 15(S)-HETrE inhibits 5-lypoxygenase with an IC_{50} of 77 mu M (arachidonic acid concentration of 60 mu M) [[Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254|{{RelationTable/GetFirstAuthor|Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254}}]]. 15(S)-HETrE is 10- to 20-fold less potent than 15(S)-HETE and 15(S)-HpETE under these experimental conditions [[Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254|{{RelationTable/GetFirstAuthor|Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254}}]].
|Biological Activity=Compared to a series of hydroxypolyenoic fatty acids, 15(S)-HETrE is a more potent inhibitor of human 5-lipoxygenase from polymorphonuclear leukocytes having an IC_{50} of 4.6 mu M at an arachidonic acid concentration of 5  mu M [[Reference:Petrich_K:Ludwig_P:Kuhn_H:Schewe_T:,Biochem. J.,1996,314 (Pt 3),911|{{RelationTable/GetFirstAuthor|Reference:Petrich_K:Ludwig_P:Kuhn_H:Schewe_T:,Biochem. J.,1996,314 (Pt 3),911}}]]. In rat basophilic leukemia cell lysates, 15(S)-HETrE inhibits 5-lypoxygenase with an IC_{50} of 77 micro M (arachidonic acid concentration of 60 mu M) [[Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254|{{RelationTable/GetFirstAuthor|Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254}}]]. 15(S)-HETrE is 10- to 20-fold less potent than 15(S)-HETE and 15(S)-HpETE under these experimental conditions [[Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254|{{RelationTable/GetFirstAuthor|Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254}}]].
}}
}}


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{{Lipid/Footer}}

Revision as of 08:37, 10 May 2010

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Upper classes: LB LBF



15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid
LBF20307HO01.png
Structural Information
15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid
  • 15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid
15(S)-HETrE
Formula C20H34O3
Exact Mass 322.25079495399996
Average Mass 322.48216
SMILES C(CCC(C=CC=CCC=CCCCCCCC(O)=O)O)CC
Physicochemical Information
15(S)-HETrE is a hydroxy fatty acid derived from dihomo- gamma -linolenic acid.
Compared to a series of hydroxypolyenoic fatty acids, 15(S)-HETrE is a more potent inhibitor of human 5-lipoxygenase from polymorphonuclear leukocytes having an IC_{50} of 4.6 mu M at an arachidonic acid concentration of 5 mu M Petrich_K et al.. In rat basophilic leukemia cell lysates, 15(S)-HETrE inhibits 5-lypoxygenase with an IC_{50} of 77 micro M (arachidonic acid concentration of 60 mu M) Haviv_F et al.. 15(S)-HETrE is 10- to 20-fold less potent than 15(S)-HETE and 15(S)-HpETE under these experimental conditions Haviv_F et al..
Spectral Information
Mass Spectra
UV Spectra λ max: 235nm ε : 23,000
IR Spectra
NMR Spectra
Other Spectra
Chromatograms
Reported Metabolites, References
Biospecies ID Compound Name Reference Comment
n.a. LBF20307HO01 See above. Haviv_F et al. 1987
n.a. LBF20307HO01 See above. Petrich_K et al. 1996