LBF20308PG03: Difference between revisions
No edit summary |
No edit summary |
||
Line 16: | Line 16: | ||
|Chemical Synthesis=[[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790|{{RelationTable/GetFirstAuthor|Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790}}]] {{Image200|LBF20308PG03FT0001.gif}} | |Chemical Synthesis=[[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790|{{RelationTable/GetFirstAuthor|Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790}}]] {{Image200|LBF20308PG03FT0001.gif}} | ||
|Metabolism=In human plasma prostaglandin D2 is dehydrated and converted to 9-deoxy-<FONT FACE="Symbol">D</FONT>9,12-13,14-dihydro-prostaglandin D2 (<FONT FACE="Symbol">D</FONT>12-prostaglandin J2) catalyzedby serum albumin [[Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739|{{RelationTable/GetFirstAuthor|Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739}}]]. | |Metabolism=In human plasma prostaglandin D2 is dehydrated and converted to 9-deoxy-<FONT FACE="Symbol">D</FONT>9,12-13,14-dihydro-prostaglandin D2 (<FONT FACE="Symbol">D</FONT>12-prostaglandin J2) catalyzedby serum albumin [[Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739|{{RelationTable/GetFirstAuthor|Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739}}]]. | ||
|Symbol=<FONT FACE="Symbol">D</FONT>12-PGJ2 | |||
|Biological Activity=<FONT FACE="Symbol">D</FONT>12-Prostaglandin J2 is considered to be an ultimate metabolite of prostaglandin D2 with anti-tumor and anti-viral activities [[Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739|{{RelationTable/GetFirstAuthor|Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739}}]]. The compound has no cell surface recptor, but is transported into cells and then inot nuclei. The biological activities of <FONT FACE="Symbol">D</FONT>12-prostaglandin J2 are due to the syntheses of various proteins including heat shock proteins, <FONT FACE="Symbol">g</FONT>-glutamylcysteine synthetase, collagen and heme oxygenase [[Reference:Negishi_M:Koizumi_T:Ichikawa_A:,J. Lipid Mediat. Cell Signal.,1995,12,443|{{RelationTable/GetFirstAuthor|Reference:Negishi_M:Koizumi_T:Ichikawa_A:,J. Lipid Mediat. Cell Signal.,1995,12,443}}]]. | |||
}} | }} | ||
{{Lipid/Footer}} | {{Lipid/Footer}} |
Revision as of 21:00, 6 January 2010
LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
IDs and Links | |
---|---|
LipidBank | XPR1911 |
LipidMaps | - |
CAS | |
KEGG | {{{KEGG}}} |
KNApSAcK | {{{KNApSAcK}}} |
mol | LBF20308PG03 |
7- [ 2 (E) - (3 (S) -Hydroxyoctylidene) -3-oxo-4-cyclopenten-1 (R) -yl ] -5 (Z) -heptenoic acid | |
---|---|
Structural Information | |
7- [ 2 (E) - (3 (S) -Hydroxyoctylidene) -3-oxo-4-cyclopenten-1 (R) -yl ] -5 (Z) -heptenoic acid | |
| |
D12-PGJ2 | |
Formula | C20H30O4 |
Exact Mass | 334.21440944799997 |
Average Mass | 334.4498 |
SMILES | C(CC[C@@H](O)CC=C(C(=O)1)[C@@H](CC=CCCCC(O)=O)C=C1)CC |
Physicochemical Information | |
METHANOL Fitzpatrick_FA et al.ETHANOL, CHLOROFORM, ETHYL ACETATE KikawaYet al. | |
Bundy_GL et al. | |
In human plasma prostaglandin D2 is dehydrated and converted to 9-deoxy-D9,12-13,14-dihydro-prostaglandin D2 (D12-prostaglandin J2) catalyzedby serum albumin Narumiya_S et al.. | |
D12-Prostaglandin J2 is considered to be an ultimate metabolite of prostaglandin D2 with anti-tumor and anti-viral activities Narumiya_S et al.. The compound has no cell surface recptor, but is transported into cells and then inot nuclei. The biological activities of D12-prostaglandin J2 are due to the syntheses of various proteins including heat shock proteins, g-glutamylcysteine synthetase, collagen and heme oxygenase Negishi_M et al.. | |
Spectral Information | |
Mass Spectra | m/e 334(M+), 316, 245, 236 KikawaYet al. |
UV Spectra | l EtOHmax = 244(e 6100)nm KikawaYet al. |
IR Spectra | n : 2930, 1700, 1640, 1580, 1232, 028 cm-1 KikawaYet al. |
NMR Spectra | 1H-NMR(CDCl3) : d 7.5(dd, 1H, 9-CH), 6.56(t, 1H, 13-CH), 6.35(dd,1 H, 10-CH), 5.48(m, 2H, 5,6-CH), 3.88(m, 1H, 15-CH), 3.44(m, 1H, 8-CH) KikawaYet al. |
Other Spectra | |
Chromatograms |
Reported Metabolites, References | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|