LBF20406AM05: Difference between revisions

Revision as of 01:52, 9 September 2010

Upper classes: LB LBF

N-Methyl- (5Z,8Z,11Z,14Z) -eicosatetraenoylamine

Structural Information
	N-Methyl- (5-cis,8-cis,11-cis,14-cis) -eicosatetraenoylamine
	N-Methyl- (5Z,8Z,11Z,14Z) -eicosatetraenoylamine N-Methylarachidonoylamide

Formula	C21H35NO
Exact Mass	317.271864747
Average Mass	317.50873999999993
SMILES	`C(CC=CCC=CCC=CCC=CCCCC(NC)=O)CCC`
Physicochemical Information
	colorless oil Sheskin_T et al.






	This compound was synthesized from arachidonoylchloride and methylamine.Yield is 67 %. Sheskin_T et al.

	Binding of this compound to the brain cannabinoid receptor (CB1),Ki(nM)= 60.0±7.4 Sheskin_T et al.


Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra	¹H NMR (CDCl3) δ 5.80 (br s, lH), 5.30-5.40 (m, 8H), 2.78-2.85 (m, 9H), 2.03-2.19 (m, 6H), 1.66-1.76 (m, 2H), 1.25-1.34 (m, 6H), 0.88 (t, J=9Hz, 3H) Sheskin_Tet al.
Other Spectra
Chromatograms

Reported Metabolites, References

Biospecies	ID	Compound Name	Reference	Comment
n.a.	LBF20406AM05	See above.	Sheskin_T et al. 1997

@@ Line 6: / Line 6: @@
 |LipidBank=XPR7021
 |LipidMaps=LMFA08020007
-|SysName=N-Methylarachidonoylamide
+|SysName=N-Methyl- (5-cis,8-cis,11-cis,14-cis) -eicosatetraenoylamine
-|Common Name=&&N-Methylarachidonoylamide&&
+|Common Name=&&N-Methyl- (5Z,8Z,11Z,14Z) -eicosatetraenoylamine&&N-Methylarachidonoylamide&&
 |Melting Point=colorless oil [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]
 |NMR Spectra=^1 H NMR (CDCl3)  delta 5.80 (br s, lH), 5.30-5.40 (m, 8H), 2.78-2.85 (m, 9H), 2.03-2.19 (m, 6H), 1.66-1.76 (m, 2H), 1.25-1.34 (m, 6H), 0.88 (t, J=9Hz, 3H) [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659|{{RelationTable/GetFirstAuthor|Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659}}]]