LBF20406HO13: Difference between revisions
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|Chemical Synthesis= | |Chemical Synthesis= | ||
|Metabolism=8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin [[Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347|{{RelationTable/GetFirstAuthor|Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347}}]]. | |Metabolism=8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin [[Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347|{{RelationTable/GetFirstAuthor|Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347}}]]. | ||
|Symbol=8(S)-HETE | |||
|Biological Activity=Both 8(S)- and 8(R)-HETEs activate mouse skin protein kinase C at a dose of 100<FONT FACE="Symbol">m</FONT>M[[Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347|{{RelationTable/GetFirstAuthor|Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347}}]]. It activates mouse keratinocyte protein kinase C with an IC<SUB><FONT SIZE=-1>5</FONT></SUB><SUB><FONT SIZE=-1>0</FONT></SUB> of 100<FONT FACE="Symbol">m</FONT>M [[Reference:Lo_HH:Bartek_GA:Fischer_SM:,Lipids,1994,29,547|{{RelationTable/GetFirstAuthor|Reference:Lo_HH:Bartek_GA:Fischer_SM:,Lipids,1994,29,547}}]]. 8(S)-HETE also activates PPAR<FONT FACE="Symbol">a</FONT> selectively at concentrations as low as 0.3<FONT FACE="Symbol">m</FONT>M [[Reference:Yu_K:Bayona_W:Kallen_CB:Harding_HP:Ravera_CP:McMahon_G:Brown_M:Lazar_MA:,J. Biol. Chem.,1995,270,23975|{{RelationTable/GetFirstAuthor|Reference:Yu_K:Bayona_W:Kallen_CB:Harding_HP:Ravera_CP:McMahon_G:Brown_M:Lazar_MA:,J. Biol. Chem.,1995,270,23975}}]]. | |||
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Revision as of 21:00, 6 January 2010
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8131 |
| LipidMaps | LMFA03060006 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406HO13 |
| 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid | |
|---|---|
| |
| Structural Information | |
| 8S-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid | |
| |
| 8(S)-HETE | |
| Formula | C20H32O3 |
| Exact Mass | 320.23514489 |
| Average Mass | 320.46628 |
| SMILES | C(CC=CCC=CC=C[C@H](CC=CCCCC(O)=O)O)CCC |
| Physicochemical Information | |
| 8(S)-HETE is a major lipoxygenase product in PMA-treated mouse epidermis Hughes_MA et al.. | |
| 8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin Hughes_MA et al.. | |
| Both 8(S)- and 8(R)-HETEs activate mouse skin protein kinase C at a dose of 100mM Hughes_MA et al.. It activates mouse keratinocyte protein kinase C with an IC50 of 100mM Lo_HH et al.. 8(S)-HETE also activates PPARa selectively at concentrations as low as 0.3mM Yu_K et al.. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | lmax: 237nm e: 27,000 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
| Reported Metabolites, References | ||||||||||||||||||||
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