LBF20406PG02: Difference between revisions

Revision as of 19:00, 25 February 2010

Upper classes: LB LBF

15-deoxy-Δ^12.14-Prostaglandin J₂

Structural Information
	11-oxo-prosta-5Z,9,12E,14Z-tetraen-1-oic acid
	15-deoxy-Δ^12.14-Prostaglandin J₂ 11-oxo-prosta-5Z,9,12E,14Z-tetraen-1-oic acid

Formula	C20H28O3
Exact Mass	316.203844762
Average Mass	316.43452
SMILES	`C(CC=CC=C(C(=O)1)[C@@H](CC=CCCCC(O)=O)C=C1)CCC`
Physicochemical Information









	15-deoxy- Delta ^{12.14}-Prostaglandin J2 induces lipogenesis and adipocyte differentiation in cultured cell line. Kliewer_SA et al. 15-deoxy- Delta ^{12.14}-Prostaglandin J2 shows powerful proapoptotic effects by inhibiting I kappa B alpha degradation. Ward_C et al.


Spectral Information
Mass Spectra
UV Spectra
IR Spectra
NMR Spectra
Other Spectra
Chromatograms

Reported Metabolites, References

Biospecies	ID	Compound Name	Reference	Comment
n.a.	LBF20406PG02	See above.	Kliewer_SA et al. 1995
n.a.	LBF20406PG02	See above.	Ward_C et al. 2002

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 |Chemical Synthesis=
 |Metabolism=
-|Biological Activity= 15-deoxy- Delta ^1 ^2 ^. ^1 ^4 -Prostaglandin J2 induces lipogenesis and adipocyte differentiation in cultured cell line.[[Reference:Kliewer_SA:Lenhard_JM:Willson_TM:Patel_I:Morris_DC:Lehmann_JM:,Cell,1995,83,813|{{RelationTable/GetFirstAuthor|Reference:Kliewer_SA:Lenhard_JM:Willson_TM:Patel_I:Morris_DC:Lehmann_JM:,Cell,1995,83,813}}]] 15-deoxy- Delta ^1 ^2 ^. ^1 ^4 -Prostaglandin J2 shows powerful proapoptotic effects by inhibiting I kappa B alpha degradation.[[Reference:Ward_C:Dransfield_I:Murray_J:Farrow_SN:Haslett_C:Rossi_AG:,J. Immunol.,2002,168,6232|{{RelationTable/GetFirstAuthor|Reference:Ward_C:Dransfield_I:Murray_J:Farrow_SN:Haslett_C:Rossi_AG:,J. Immunol.,2002,168,6232}}]]
+|Biological Activity= 15-deoxy- Delta ^{12.14}-Prostaglandin J2 induces lipogenesis and adipocyte differentiation in cultured cell line.[[Reference:Kliewer_SA:Lenhard_JM:Willson_TM:Patel_I:Morris_DC:Lehmann_JM:,Cell,1995,83,813|{{RelationTable/GetFirstAuthor|Reference:Kliewer_SA:Lenhard_JM:Willson_TM:Patel_I:Morris_DC:Lehmann_JM:,Cell,1995,83,813}}]] 15-deoxy- Delta ^{12.14}-Prostaglandin J2 shows powerful proapoptotic effects by inhibiting I kappa B alpha degradation.[[Reference:Ward_C:Dransfield_I:Murray_J:Farrow_SN:Haslett_C:Rossi_AG:,J. Immunol.,2002,168,6232|{{RelationTable/GetFirstAuthor|Reference:Ward_C:Dransfield_I:Murray_J:Farrow_SN:Haslett_C:Rossi_AG:,J. Immunol.,2002,168,6232}}]]
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