Category:LBS

Sphingolipid

Class Overview

Sphingosine & Ceramide

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
The Sphingolipid category (LBS) in this database includes glycosphingolipid, phosphosphingolipid, and ceramide.

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。 スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
このデータベースにおけるスフィンゴ脂質カテゴリー (LBS) には、スフィンゴ糖脂質 (glycosphingolipid)、スフィンゴリン脂質 (phosphosphingolipid) 、セラミド (ceramide) が含まれています。

Abbreviations

Page/ID Design for Sphingolipid

L B S s1 s2 s3 n1 n2 y c c1 c2

  • s1 ∼ s3 ... Structure code (3 digits)
Explained below
  • n1, n2 ... the number of sugars (2 digits)
  • y ... the number of sialic acids ( 1 digit)
  • c ... ceramide identification (1 digit)
  • c1, c2 ... serial numbers

  • s1 ∼ s3 ... 構造コード (3桁）
下に詳述
  • n1, n2 ... 糖の数 (2桁)
  • y ... シアル酸の数 (1桁)
  • c ... セラミドの同定 (1桁)
  • c1, c2 ... 通し番号

Structure Code

NOTE

Most common patterns
  • GalNAcβ1-4Galβ1-4-Glcβ1-Cer:Ganglio series ... over 110 molecules
  • GlcNAcβ1-3Galβ1-4-Glcβ1-Cer:Lacto or Neolacto series ... over 170 molecules
  • Neuraminic acid + Galβ1-4-Glcβ1-Cer:??... over 50 molecules
  • GlcNAcβ1-3Manβ1-4Glcβ1-1Cer:Arthro series ... over 50 molecules


Digits

"I" and "O" are not used to avoid confusion with "1" or "0".

code sugar code sugar code sugar
0 no sugar A GlcNAcβ1-3 L Pentose sugars (Ara, Xyl)
1 Galα1-3 B GlcNAcβ1-4 M Mannose and Rhamnose (= 6-deoxymannose) (Man, Rha)
2 Galα1-4 C GlcNAcβ1-6 N Neuraminic acids (NeuAc, NeuNH, NeuGc, KDN)
3 Galα1-6 D GalNAc, GalN P Phosphocholine (PC), Phosphate (HPO3), Sulphate (HSO3)
4 Galβ1-3 E GlcNAc, GlcN Q Aminoethylphosphates (AEPn, MAEPr, EtnP)
5 Galβ1-4 F Other Galactose (Gal) R O-Alkyl and O-acyl groups including ethylene (OAc, CH3, 2C=CH)
6 Galβ1-6 G Other Glucose (Glc)
7 GalNAcβ1-3
8 GalNAcβ1-4 J Inositol Y GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
9 GalNAcβ1-6 K Fucose (Fuc) Z Galβ1-4Glcβ1-1bCer

Polysaccharide Chain

Table 1. Common Categories
Common Name Sequence LipidBank ID
By GalCer Synthase (EC 2.4.1.62)
Gala 0 Galα1-4Galβ1-Cer
Spirometo 0 Galβ1-4Glcβ1-3Galβ1-Cer
By GlcCer Synthase (EC 2.4.1.80)
Ganglio 0 GalNAcβ1-4Galβ1-4Glcβ1-Cer
Isoganglio 0 GalNAcβ1-3Galβ1-4Glcβ1-Cer
Globo 0 Galα1-4Galβ1-4Glcβ1-Cer
Isoglobo 0 Galα1-3Galβ1-4Glcβ1-Cer
Lacto 0 Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ1-Cer
NeoLacto 0 Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer
Muco 0 Galβ1-4Galβ1-4Glcβ1-Cer
With Mannose
Arthro 0 GlcNAcβ1-3Manβ1-4Glcβ1-Cer
Mollu 0 Manα1-3Manβ1-4Glcβ1-Cer

Classification

By the Number of Sugars 糖の個数

For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP.

スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。

Sphingolipid Overview

Glycosphingolipid
スフィンゴ糖脂質: LBSnn
LBSnn.png

Phosphosphingolipid
スフィンゴリン脂質: LBSPP
LBSPP.png

Table 1. Classification by the Number of Sugars
 
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Subcategories

This category has the following 4 subcategories, out of 4 total.

L

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