Category:LBS: Difference between revisions

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{{Twocolumn|
{{Twocolumn|
The Sphingolipid category (LBS) in this database:
Three Sphingolipid categories (LBS) exist in this database.
|このデータベースではスフィンゴ脂質を以下に分けています。
|このデータベースではスフィンゴ脂質を以下に分けています。
}}
}}
<center>
<center>
{|  
{|  
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[[:Category:LBSB| '''Ceramide''']]<br/>{{LBS/Cer|OH}}<br/><small>セラミド</small>
[[:Category:LBSB| '''Ceramide''']]<br/>{{LBS/Cer|OH}}<br/><small>セラミド</small>
| style="vertical-align:top" width="33%"|
| style="vertical-align:top" width="33%"|
[[:Category:LBSG| '''Glycosphingolipid''']]<br/>{{LBS/Cer|O-(sugar)}}<br/><small>スフィンゴ糖脂質</small>
[[:Category:LBS#スフィンゴ糖脂質 Glycosphingolipid|'''Glycosphingolipid''']]<br/>{{LBS/Cer|O-(sugar)}}<br/><small>スフィンゴ糖脂質</small>
| style="vertical-align:top" width="33%"|
| style="vertical-align:top" width="33%"|
[[:Category:LBSP| '''Phosphosphingolipid''']]<br/>{{LBS/Cer|O-(phosphate)}}<br/><small>スフィンゴリン脂質</small>
[[:Category:LBSP| '''Phosphosphingolipid''']]<br/>{{LBS/Cer|O-(phosphate)}}<br/><small>スフィンゴリン脂質</small>
|-
|-
|
|
*[[:Category:LBSB|Ceramide and long chain bases]]
*[[:Category:LBSB|Long-chain base and ceramide]]
|  
|
*[[:Category:LBSC|Cerebroside <small>(monohexosyl ceramides)</small>]]
*[[:Category:LBSC|Cerebroside <small>(monohexosyl ceramides)</small>]]
*[[:Category:LBSG|Glycosylceramide <small>(polyhexosyl ceramides)</small>]]
*[[:Category:LBSG|Acidic glycosphingolipid]]
|
|
*[[:Category:LBSP|Sphingomyelins and GIPC]]
*[[:Category:LBSP|Sphingomyelin, CPE, CAEP and GIPC]]
|}
|}
</center>
</center>


==={{Bilingual|スフィンゴ脂質の歴史|History of Sphingolipids}}===
<center>
{{Twocolumn|
{| class="wikitable"
Sphingolipids were first isolated from brain by J.L.W. Thudichum (1829-1901) as lipids of unknown function and structure.<ref>Thudichum J.L.W. "A Treatise on the Chemical Constitution of the Balliere" Tindall and Cox, London, 1884</ref> The basic structure is a long-chain base (long-chain amino-alcohol) whose amino-group is acylated with a long-chain fatty acid. This hydrophobic structure is called ceramides.
|<big>
Sphingolipid consists of phospho-sphingolipid and glyco-sphingolipid, whose ceramide structure is bonded with phosphate and (poly)saccharides, respectively. Phosphosphingolipid includes sphingomyelin, and glycosphingolipid, cerebrosides and gangliosides. Both are abundant in neural tissues.<ref>Gault CR, Obeid LM, Hannun YA "An overview of sphingolipid synthesis to breakdown" Adv Exp Med Biol. 2010;688:1-23. PMID 20919643</ref>
[[:Category:LBS/Search|{{Bilingual|スフィンゴ脂質検索画面にいく|Go to Sphingolipid search.}}]]
|
</big>
スフィンゴ脂質は J.L.W. Thudichum (1829-1901) により機能や構造未知の脂質として脳から見いだされました。基本骨格は長鎖塩基 (長鎖アミノアルコール) のアミノ基が長鎖脂肪酸とアミド結合したもので、セラミドと呼ばれます。
|}
スフィンゴ脂質はセラミドにリン酸が結合したスフィンゴリン脂質と糖が結合したスフィンゴ糖脂質に分けられます。スフィンゴリン脂質にはスフィンゴミエリンが、スフィンゴ糖脂質にはセレブロシドやガングリオシドなどが含まれ、いずれも神経系に多く存在します。
</center>
}}


<references/>


=={{Bilingual|スフィンゴ脂質|Sphingolipid}}==
==スフィンゴ脂質 Sphingolipid==


==={{Bilingual|表記法|Notation}}===
==={{Bilingual|表記法|Notation}}===
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|}
|}


==={{Bilingual|分類体系|Page/ID-Code Design}}===
===分類体系 ID-Code Design===
{{Twocolumn|
{{Twocolumn|
Major series of phosphosphingolipids are determined by molecules bound to their phosphates, and the series of glycosphingolipids are determined by polysaccharides bound to their ceramides. The IUPAC series of glycosphingolipids (1977) were based on the order and bonding patterns of four sugars rooting at the long-chain base. Our series, however, are based on three sugars. Two original series, Echino and Schisto, are also added.
Major series of phosphosphingolipids are determined by molecules bound to their phosphates, and the series of glycosphingolipids are determined by oligosaccharides bound to their ceramides. The IUPAC series of glycosphingolipids (1977) were based on the order and bonding patterns of four sugars rooting at the long-chain base. Our series, however, are based on three sugars. Two original series, Echino and Schisto, are also added.
|スフィンゴリン脂質はリン酸に結合する分子や糖の種類、スフィンゴ糖脂質はセラミドに結合する糖鎖により系列を作成しています。1977年にIUPACが提唱したスフィンゴ糖脂質の系列は、長鎖塩基に結合する四糖の並びと結合を基準にしています。ここではより広い糖鎖の系列を検索できるよう、三糖を基準に分類しています。また新たにEchinoとSchistoの系列を加えています。
|スフィンゴリン脂質はリン酸に結合する分子や糖の種類、スフィンゴ糖脂質はセラミドに結合する糖鎖により系列を作成しています。1977年にIUPACが提唱したスフィンゴ糖脂質の系列は、長鎖塩基に結合する四糖の並びと結合を基準にしています。ここではより広い糖鎖の系列を検索できるよう、三糖を基準に分類しています。また新たにEchinoとSchistoの系列を加えています。
}}
}}
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|}
|}


==={{Bilingual|スフィンゴ糖脂質１文字目|First (s1) Digit for Glycosphingolipid}}===
===スフィンゴ糖脂質 Glycosphingolipid===
<span id="SphingolipidClass"></span>
<span id="SphingolipidClass"></span>
{| class="wikitable" style="text-align:right; background-color:white"
{| class="wikitable" style="text-align:right; background-color:white"
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|-
|-
! starting with<br/><big>Galactose</big>
! starting with<br/><big>Galactose</big>
| [[Volatile:ListMol/LBStitle|LBSG1|'''G1''']] <br/> ([[Volatile:ClassMatrix|LBSG1.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG1}} items]])
| {{#volatile:ListMol/LBStitle|<b>G1</b>|LBSG1}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG1}} items|LBSG1.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''Gal'''-Cer
|style="text-align:right"| '''Gal'''-Cer
|
|
{| style="width:100%;"
{| style="width:100%;"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Gala1-4?6?Galb1-Cer|Gala / Neogala]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Gala / Neogala|Mainchain.*Gala1-4?6?Galb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Gala1-4/6Galb1-Cer}}  
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Gala1-4/6Galb1-Cer}}  
|-
|-
|style="border:0;text-align:left"|[[Volatile:ListMol/LBS|Mainchain.*Galb1-4Glcb1-3Galb1-Cer|Spirometo]]
|style="border:0;text-align:left"|{{#volatile:ListMol/LBS|Spirometo|Mainchain.*Galb1-4Glcb1-3Galb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Galb1-4Glcb1-3Galb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Galb1-4Glcb1-3Galb1-Cer}}
|}
|}
|-
|-
! rowspan="8" | starting with<br/><big>Glucose</big>
! rowspan="8" | starting with<br/><big>Glucose</big>
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG2|'''G2''']] <br/> ([[Volatile:ClassMatrix|LBSG2.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG2}} items]])
| {{#volatile:ListMol/LBStitle|<b>G2</b>|LBSG2}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG2}} items|LBSG2.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''GalNAc<sub>&beta;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|style="text-align:right"| '''GalNAc<sub>&beta;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GalNAcb1-4Galb1-4Glcb1-Cer|Ganglio]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Ganglio|Mainchain.*GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-4Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GalNAcb1-3Galb1-4Glcb1-Cer|Isoganglio]]<ref name="iso">In IUPAC, "iso" refers to a change from position 4 to position 3.</ref>
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Isoganglio|Mainchain.*GalNAcb1-3Galb1-4Glcb1-Cer}}<ref name="iso">In IUPAC, "iso" refers to a change from position 4 to position 3.</ref>
|style="border:0;text-align:right"| {{LBS/FormatSugar|GalNAcb1-3Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-3Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*GlcNAcb1-3\(.*GalNAcb1-4\)Galb1-4Glcb1-Cer|Lactoganglio]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Lactoganglio|Structure.*GlcNAcb1-3\(.*GalNAcb1-4\)Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|GlcNAcb1-3(GalNAcb1-4)Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GlcNAcb1-3(GalNAcb1-4)Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*\(?NeuAca2-3\)?Galb1-4Glcb1-Cer|a-series]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|a-series|Structure.*\(?NeuAca2-3\)?Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|(NeuAca2-3)Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-4(NeuAca2-3)Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*\(?NeuAca2-8NeuAca2-3\)?Galb1-4Glcb1-Cer|b-series]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|b-series|Structure.*\(?NeuAca2-8NeuAca2-3\)?Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|(NeuAca2-8NeuAca2-3)Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-4(NeuAca2-8NeuAca2-3)Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*\(?NeuAca2-8NeuAca2-8NeuAca2-3\)?Galb1-4Glcb1-Cer|c-series]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|c-series|Structure.*\(?NeuAca2-8NeuAca2-8NeuAca2-3\)?Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|(NeuAca2-8NeuAca2-8NeuAca2-3)Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-4(NeuAca2-8NeuAca2-8NeuAca2-3)Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*\(?NeuAca2-6\)?GalNAcb1-4Galb1-4Glcb1-Cer|&alpha;-series]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|&alpha;-series|Structure.*\(?NeuAca2-6\)?GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|(NeuAca2-6)GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|...(NeuAca2-6)GalNAcb1-4Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Structure.*\(?NeuAca2-8NeuAca2-6\)?GalNAcb1-4Galb1-4Glcb1-Cer|&beta;-series]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|&beta;-series|Structure.*\(?NeuAca2-8NeuAca2-6\)?GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|(NeuAca2-8NeuAca2-6)GalNAcb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|...(NeuAca2-8NeuAca2-6)GalNAcb1-4Galb1-4Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG3|'''G3''']] <br/> ([[Volatile:ClassMatrix|LBSG3.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG3}} items]])
| {{#volatile:ListMol/LBStitle|<b>G3</b>|LBSG3}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG3}} items|LBSG3.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''GlcNAc<sub>&beta;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|style="text-align:right"| '''GlcNAc<sub>&beta;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Galb1-3GlcNAcb1-3Galb1-4Glcb1-Cer|Lacto]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Lacto|Mainchain.*Galb1-3GlcNAcb1-3Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Galb1-3GlcNAcb1-3Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Galb1-3GlcNAcb1-3Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Gal.1-4GlcNAcb1-3Galb1-4Glcb1-Cer|Neolacto]]<ref name="neo">In IUPAC, "neo" refers to a change from position 3 to position 4.</ref>
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Neolacto|Mainchain.*Gal.1-4GlcNAcb1-3Galb1-4Glcb1-Cer}}<ref name="neo">In IUPAC, "neo" refers to a change from position 3 to position 4.</ref>
|style="border:0;text-align:right"| {{LBS/FormatSugar|Galb1-4GlcNAcb1-3Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Galb1-4GlcNAcb1-3Galb1-4Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBS|LBSG4|'''G4''']] <br/> ([[Volatile:ClassMatrix|LBSG4.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG4}} items]])
| {{#volatile:ListMol/LBStitle|<b>G4</b>|LBSG4}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG4}} items|LBSG4.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''Gal<sub>&alpha;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|style="text-align:right"| '''Gal<sub>&alpha;</sub>'''-Gal<sub>&beta;</sub>-Glc<sub>&beta;</sub>-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Gala1-4Galb1-4Glcb1-Cer|Globo]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Globo|Mainchain.*Gala1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Gala1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Gala1-4Galb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Gala1-3Galb1-4Glcb1-Cer|Isoglobo]]<ref name="iso"/>
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Isoglobo|Mainchain.*Gala1-3Galb1-4Glcb1-Cer}}<ref name="iso"/>
|style="border:0;text-align:right"| {{LBS/FormatSugar|Gala1-3Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Gala1-3Galb1-4Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG5|'''G5''']] <br/> ([[Volatile:ClassMatrix|LBSG5.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG5}} items]])
| {{#volatile:ListMol/LBStitle|<b>G5</b>|LBSG5}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG5}} items|LBSG5.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| Gal-Glc-Cer<br/>(Other than G2&sim;G4)
|style="text-align:right"| Gal-Glc-Cer<br/>(Other than G2&sim;G4)
|
|
{| style="width:100%"
{| style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Galb1-4Galb1-4Glcb1-Cer|Muco]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Muco|Mainchain.*Galb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Galb1-4Galb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Galb1-4Galb1-4Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG6|'''G6''']] <br/> ([[Volatile:ClassMatrix|LBSG6.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG6}} items]])
| {{#volatile:ListMol/LBStitle|<b>G6</b>|LBSG6}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG6}} items|LBSG6.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''Man'''-Glc<sub>&beta;</sub>-Cer
|style="text-align:right"| '''Man'''-Glc<sub>&beta;</sub>-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GlcNAcb1-3Manb1-4Glcb1-Cer|Arthro]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Arthro|Mainchain.*GlcNAcb1-3Manb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|GlcNAcb1-3Manb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GlcNAcb1-3Manb1-4Glcb1-Cer}}
|-
|-
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Mana1-3Manb1-4Glcb1-Cer|Mollu]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Mollu|Mainchain.*Mana1-3Manb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|Mana1-3Manb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Mana1-3Manb1-4Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG7|'''G7''']] <br/> ([[Volatile:ClassMatrix|LBSG7.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG7}} items]])
| {{#volatile:ListMol/LBStitle|<b>G7</b>|LBSG7}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG7}} items|LBSG7.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''NeuAc'''/'''NeuGc'''-Glc<sub>&beta;</sub>-Cer
|style="text-align:right"| '''NeuAc'''/'''NeuGc'''-Glc<sub>&beta;</sub>-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Neu(A~G)c.2-6Glcb1-Cer|Echino]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Echino|Mainchain.*Neu(A~G)c.2-6Glcb1-Cer}}
|style="border:0;text-align:right"| <font color=purple>'''NeuGc'''</font> or {{LBS/FormatSugar|NeuAca2-6Glcb1-Cer}}
|style="border:0;text-align:right"| <font color=purple>'''NeuGc'''</font> or {{#invoke:LBS|FormatSugar|NeuAca2-6Glcb1-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSG8|'''G8''']] <br/> ([[Volatile:ClassMatrix|LBSG8.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids|{{#countTitle:LBSG8}} items]])
| {{#volatile:ListMol/LBStitle|<b>G8</b>|LBSG8}} <br /> ({{#volatile:ClassMatrix|{{#countTitle:LBSG8}} items|LBSG8.....|7|8|9|9|Number_of_Sugars|Number_of_Sialic_acids}})
|style="text-align:right"| '''GalNAc'''-Glc-Cer
|style="text-align:right"| '''GalNAc'''-Glc-Cer
|
|
{| style="width:100%"
{| style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GalNAc.1-4Glc.1-Cer|Schisto]]<ref>Makaaru CK, Damian RT, Smith DF, Cummings RD. "The human blood fluke Schistosoma mansoni synthesizes a novel type of glycosphingolipid" J Biol Chem 1992 267:2251-2257 PMID 1733932</ref>
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Schisto|Mainchain.*GalNAc.1-4Glc.1-Cer}}<ref>Makaaru CK, Damian RT, Smith DF, Cummings RD. "The human blood fluke Schistosoma mansoni synthesizes a novel type of glycosphingolipid" J Biol Chem 1992 267:2251-2257 PMID 1733932</ref>
|style="border:0;text-align:right"| {{LBS/FormatSugar|GalNAcb1-4Glcb1-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GalNAcb1-4Glcb1-Cer}}
|}
|}
|-
|-
! starting with<br/><big>Other Sugars</big>
! starting with<br/><big>Other Sugars</big>
| [[Volatile:ListMol/LBStitle|LBSG(A~B~C~D~E~F~G~H~J~K~M~N~O~P~Q~R)|'''G'''('''A'''&sim;'''R''')]]
| {{#volatile:ListMol/LBStitle|<b>G</b>(<b>A</b>&sim;<b>R</b>)|LBSG(A~B~C~D~E~F~G~H~J~K~M~N~O~P~Q~R)}}
|colspan="2"| Symbols follow the Sugar-digit table.
|colspan="2"| Symbols follow the [[:Category:LBS#Sugar-Digit Table]].
|}
|}
<references/>
<references/>


==={{Bilingual|スフィンゴリン脂質１文字目|First (s1) Digit for Phosphosphingolipid}}===
===スフィンゴリン脂質 Phosphosphingolipid===
{| class="wikitable" style="text-align:right; background-color:white"
{| class="wikitable" style="text-align:right; background-color:white"
! First sugar || Code || Root sequence  
! First sugar || Code || Root sequence  
Line 259: Line 258:
|-
|-
! rowspan="4" | starting with<br/><big>Inositol</big>
! rowspan="4" | starting with<br/><big>Inositol</big>
| [[Volatile:ListMol/LBStitle|LBSP2|'''P2''']] <br/> ({{#countTitle:LBSP2}} items)
| {{#volatile:ListMol/LBStitle|<b>P2</b>|LBSP2}} <br /> ({{#countTitle:LBSP2}} items)
| style="text-align:right"| '''GlcN'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
| style="text-align:right"| '''GlcN'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
|
|
{|style="width:100%"
{|style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GlcN.1-.Ins-P-Cer|Protozoa & Fungi-specific]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Protozoa & Fungi-specific|Mainchain.*GlcN.1-.Ins-P-Cer}}
| style="border:0;text-align:right"| {{LBS/FormatSugar|GlcNa/b1-2/6Ins1-P-Cer}}
| style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GlcNa/b1-2/6Ins1-P-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSP3|'''P3''']] <br/> ({{#countTitle:LBSP3}} items)  
| {{#volatile:ListMol/LBStitle|<b>P3</b>|LBSP3}} <br /> ({{#countTitle:LBSP3}} items)  
|style="text-align:right"| '''GlcA'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
|style="text-align:right"| '''GlcA'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
|
|
{|style="width:100%"
{|style="width:100%"
|style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*GlcA.1-.Ins-P-Cer|Plant-specific]]
|style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Plant-specific|Mainchain.*GlcA.1-.Ins-P-Cer}}
|style="border:0;text-align:right"| {{LBS/FormatSugar|GlcAa/b1-2/6Ins1-P-Cer}}
|style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|GlcAa/b1-2/6Ins1-P-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSP4|'''P4''']] <br/> ({{#countTitle:LBSP4}} items)
| {{#volatile:ListMol/LBStitle|<b>P4</b>|LBSP4}} <br /> ({{#countTitle:LBSP4}} items)
| style="text-align:right"| '''Man'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
| style="text-align:right"| '''Man'''<sub>&alpha;/&beta;1&minus;2/6</sub>Ins<sub>1</sub>-P-Cer
|
|
{| style="width:100%"
{| style="width:100%"
| style="border:0;text-align:left"| [[Volatile:ListMol/LBS|Mainchain.*Man.1-.Ins-P-Cer|Fungi-specific]]
| style="border:0;text-align:left"| {{#volatile:ListMol/LBS|Fungi-specific|Mainchain.*Man.1-.Ins-P-Cer}}
| style="border:0;text-align:right"| {{LBS/FormatSugar|Mana/b1-2/6Ins1-P-Cer}}
| style="border:0;text-align:right"| {{#invoke:LBS|FormatSugar|Mana/b1-2/6Ins1-P-Cer}}
|}
|}
|-
|-
| [[Volatile:ListMol/LBStitle|LBSP5|'''P5''']] <br/> ({{#countTitle:LBSP5}} items)
| {{#volatile:ListMol/LBStitle|<b>P5</b>|LBSP5}} <br /> ({{#countTitle:LBSP5}} items)
| style="text-align:right"| Others
| style="text-align:right"| Gal, Glc, and Others
| style="text-align:right"| {{LBS/FormatSugar|Ins1-P-Cer}}
| style="text-align:right"| {{#invoke:LBS|FormatSugar|X-Ins1-P-Cer}}
|}
|}


==={{Bilingual|コード２文字目|Second (s2) Digit}}===
===Sugar-Digit Table===
<span id="SphingolipidSugar"></span>
<span id="SphingolipidSugar"></span>
{{Bilingual|クリックすると一覧が出ます。記号の略称については|Click to see the full list. For abbreviations, see}} [[#Notation]].
{{Bilingual|クリックすると一覧が出ます。記号の略称については|Click to see the full list. For abbreviations, see}} [[#Notation]].
Line 332: Line 331:
|-
|-
! '''J'''
! '''J'''
| [[Volatile:ListMol/LBS|Structure.*Man|Mannose]] [[File:LBS-Monomer-Man.png]]
| {{#volatile:ListMol/LBS|Mannose|Structure.*Man}} [[File:LBS-Monomer-Man.png]]
|-
|-
! '''K'''
! '''K'''
| [[Volatile:ListMol/LBS|Structure.*Rha|Rhamnose]] [[File:LBS-Monomer-Rha.png]]
| {{#volatile:ListMol/LBS|Rhamnose|Structure.*Rha}} [[File:LBS-Monomer-Rha.png]]
|-
|-
! '''L'''
! '''L'''
| [[Volatile:ListMol/LBS|{{#encode:Structure.*Ins(Me)?-P-[^Cer]}}|Inositol]]
| {{#volatile:ListMol/LBS|Inositol|Structure.*Ins(Me)?-P-[^Cer]}}  
|-
|-
! '''M'''
! '''M'''
| Fucose ([[Volatile:ListMol/LBS|{{#encode:Structure[^F]+Fuc[^F]+$}}| 1]], [[Volatile:ListMol/LBS|{{#encode:Structure([^F]+Fuc){2}[^F]+$}}|2]], [[Volatile:ListMol/LBS|{{#encode:Structure([^F]+Fuc){3}}}|>3]]) [[File:LBS-Monomer-Fuc.png]]
| Fucose ({{#volatile:ListMol/LBS| 1|Structure[^F]+Fuc[^F]+$}}, {{#volatile:ListMol/LBS|2|Structure([^F]+Fuc){2}[^F]+$}}, {{#volatile:ListMol/LBS|>3|Structure([^F]+Fuc){3} }}) [[File:LBS-Monomer-Fuc.png]]
|-
|-
! '''N'''
! '''N'''
| [[Volatile:ListMol/LBS|Structure.*Ara|Arabinose]] [[File:LBS-Monomer-Ara.png]]
| {{#volatile:ListMol/LBS|Arabinose|Structure.*Ara}} [[File:LBS-Monomer-Ara.png]]
|-
|-
! '''O'''
! '''O'''
| [[Volatile:ListMol/LBS|Structure.*Xyl|Xylose]] [[File:LBS-Monomer-Xyl.png]]
| {{#volatile:ListMol/LBS|Xylose|Structure.*Xyl}} [[File:LBS-Monomer-Xyl.png]]
|-
|-
! '''P'''
! '''P'''
| [[Volatile:ListMol/LBS|Structure.*(NeuAc~NeuNH)|NeuAc / NeuNH]] [[File:LBS-Monomer-NeuAc.png]]
| {{#volatile:ListMol/LBS|NeuAc / NeuNH|Structure.*(NeuAc~NeuNH)}} [[File:LBS-Monomer-NeuAc.png]]
|-
|-
! '''Q'''
! '''Q'''
| [[Volatile:ListMol/LBS|Structure.*(NeuGc)|NeuGc]] [[File:LBS-Monomer-NeuGc.png]]
| {{#volatile:ListMol/LBS|NeuGc|Structure.*(NeuGc)}} [[File:LBS-Monomer-NeuGc.png]]
|-
|-
! '''R'''
! '''R'''
| [[Volatile:ListMol/LBS|Structure.*(KDN)|Kdn]] [[File:LBS-Monomer-KDN.png]]
| {{#volatile:ListMol/LBS|Kdn|Structure.*(KDN)}} [[File:LBS-Monomer-KDN.png]]
|}
|}
|valign="top"|
|valign="top"|
Line 364: Line 363:
|-
|-
! '''S'''
! '''S'''
| [[Volatile:ListMol/LBS|Structure.*(Phospho)|Phosphate (except GIPC)]] [[File:LBS-Monomer-P.png]]
| {{#volatile:ListMol/LBS|Phosphate (except GIPC)|Structure.*(Phospho)}} [[File:LBS-Monomer-P.png]]
|-
|-
! '''T'''
! '''T'''
| [[Volatile:ListMol/LBS|Structure.*(AEPn)|(M)AEPn]], [[Volatile:ListMol/LBS|Structure.*(EtnP)|EtnP]], [[Volatile:ListMol/LBS|Structure.*(PC)|PC]] [[File:LBS-Monomer-AEPn.png]]
| {{#volatile:ListMol/LBS|(M)AEPn|Structure.*(AEPn)}}, {{#volatile:ListMol/LBS|EtnP|Structure.*(EtnP)}}, {{#volatile:ListMol/LBS|PC|Structure.*(PC)}} [[File:LBS-Monomer-AEPn.png]]
|-
|-
! '''U'''
! '''U'''
| [[Volatile:ListMol/LBS|Structure.*Sulfo|Sulfate]] [[File:LBS-Monomer-S.png]]
| {{#volatile:ListMol/LBS|Sulfate|Structure.*Sulfo}} [[File:LBS-Monomer-S.png]]
|-
|-
! '''V'''
! '''V'''
Line 383: Line 382:
}}
}}


=={{Bilingual|スフィンゴ脂質の歴史|History of Sphingolipids}}==
{{Twocolumn|
Sphingolipids were first isolated from brain by J.L.W. Thudichum (1829-1901) as lipids of unknown function and structure.<ref>Thudichum J.L.W.?"A Treatise on the Chemical Constitution of the Balliere" Tindall and Cox, London,?1884</ref> The basic structure is a long-chain base (long-chain amino-alcohol) whose amino-group is acylated with a long-chain fatty acid. This hydrophobic structure is called ceramides.
Sphingolipid consists of phospho-sphingolipid and glyco-sphingolipid, whose ceramide structure is bonded with phosphate and (oligo)saccharides, respectively. Phosphosphingolipid includes sphingomyelin, and glycosphingolipid, cerebrosides and gangliosides. Both are abundant in neural tissues.<ref>Gault CR,?Obeid LM,?Hannun YA "An overview of sphingolipid synthesis to breakdown" Adv Exp Med Biol.?2010;688:1-23. PMID 20919643</ref>
|
スフィンゴ脂質は J.L.W. Thudichum (1829-1901) により機能や構造未知の脂質として脳から見いだされました。基本骨格は長鎖塩基 (長鎖アミノアルコール) のアミノ基が長鎖脂肪酸とアミド結合したもので、セラミドと呼ばれます。
スフィンゴ脂質はセラミドにリン酸が結合したスフィンゴリン脂質と糖が結合したスフィンゴ糖脂質に分けられます。スフィンゴリン脂質にはスフィンゴミエリンが、スフィンゴ糖脂質にはセレブロシドやガングリオシドなどが含まれ、いずれも神経系に多く存在します。
}}
<references/>


<!---
<!---
Line 396: Line 406:
| '''1'''  
| '''1'''  
|rowspan="3"| <b>Galactose</b><br/>(&alpha; form)
|rowspan="3"| <b>Galactose</b><br/>(&alpha; form)
| {{LBS/FormatSugar|Gala1-3 ...}}
| {{#invoke:LBS|FormatSugar|Gala1-3 ...}}
|-
|-
| '''2''' || {{LBS/FormatSugar|Gala1-4 ...}}
| '''2''' || {{#invoke:LBS|FormatSugar|Gala1-4 ...}}
|-
|-
| '''3''' || {{LBS/FormatSugar|Gala1-6 ...}}
| '''3''' || {{#invoke:LBS|FormatSugar|Gala1-6 ...}}
|-
|-
| '''4'''
| '''4'''
|rowspan="3"| <b>Galactose</b><br/>(&beta; form)
|rowspan="3"| <b>Galactose</b><br/>(&beta; form)
| {{LBS/FormatSugar|Galb1-3 ...}}
| {{#invoke:LBS|FormatSugar|Galb1-3 ...}}
|-
|-
| '''5''' || {{LBS/FormatSugar|Galb1-4 ...}}
| '''5''' || {{#invoke:LBS|FormatSugar|Galb1-4 ...}}
|-
|-
| '''6''' || {{LBS/FormatSugar|Galb1-6 ...}}
| '''6''' || {{#invoke:LBS|FormatSugar|Galb1-6 ...}}
|}
|}
|valign="top"|
|valign="top"|
Line 418: Line 428:
| '''7'''  
| '''7'''  
|rowspan="3"| <b>''N''-Acetyl Galactosamine</b><br/>(&beta; form)
|rowspan="3"| <b>''N''-Acetyl Galactosamine</b><br/>(&beta; form)
| {{LBS/FormatSugar|GalNAcb1-3 ...}}
| {{#invoke:LBS|FormatSugar|GalNAcb1-3 ...}}
|-
|-
| '''8''' || {{LBS/FormatSugar|GalNAcb1-4 ...}}
| '''8''' || {{#invoke:LBS|FormatSugar|GalNAcb1-4 ...}}
|-
|-
| '''9''' || {{LBS/FormatSugar|GalNAcb1-6 ...}}
| '''9''' || {{#invoke:LBS|FormatSugar|GalNAcb1-6 ...}}
|-
|-
| '''A'''  
| '''A'''  
|rowspan="3"| <b>''N''-Acetyl Glucosamine</b><br/>(&beta; form)
|rowspan="3"| <b>''N''-Acetyl Glucosamine</b><br/>(&beta; form)
| {{LBS/FormatSugar|GlcNAcb1-3 ...}}
| {{#invoke:LBS|FormatSugar|GlcNAcb1-3 ...}}
|-
|-
| '''B'''
| '''B'''
| {{LBS/FormatSugar|GlcNAcb1-4 ...}}
| {{#invoke:LBS|FormatSugar|GlcNAcb1-4 ...}}
|-
|-
| '''C'''
| '''C'''
| {{LBS/FormatSugar|GlcNAcb1-6 ...}}
| {{#invoke:LBS|FormatSugar|GlcNAcb1-6 ...}}
|}
|}
|}
|}
Line 445: Line 455:
| '''D'''  
| '''D'''  
|rowspan="2"| <b>Aminated Sugars</b><br/>(Except for Code 7&sim;C)
|rowspan="2"| <b>Aminated Sugars</b><br/>(Except for Code 7&sim;C)
| {{LBS/FormatSugar|GalNAc, GalN}}
| {{#invoke:LBS|FormatSugar|GalNAc, GalN}}
|-
|-
| '''E''' || {{LBS/FormatSugar|GlcNAc, GlcN}}
| '''E''' || {{#invoke:LBS|FormatSugar|GlcNAc, GlcN}}
|-
|-
| '''F'''  
| '''F'''  
Line 491: Line 501:
!colspan="2"| Abbreviations
!colspan="2"| Abbreviations
|-
|-
| '''Y''' || {{LBS/FormatSugar|GlcNAcb1-3Manb1-4Glcb1-1Cer}}
| '''Y''' || {{#invoke:LBS|FormatSugar|GlcNAcb1-3Manb1-4Glcb1-1Cer}}
|-
|-
| '''Z''' || {{LBS/FormatSugar|Galb1-4Glcb1-1bCer}}
| '''Z''' || {{#invoke:LBS|FormatSugar|Galb1-4Glcb1-1bCer}}
|}
|}
|}
|}

Latest revision as of 06:42, 28 May 2024

Sphingolipid


Upper classes: LB

Class Overview

Three Sphingolipid categories (LBS) exist in this database.

このデータベースではスフィンゴ脂質を以下に分けています。

Ceramide
| OH
(C14-chain)＝／＼／ーOH
(fatty acid) ー | NH

セラミド 		Glycosphingolipid
| OH
(C14-chain)＝／＼／ーO-(sugar)
(fatty acid) ー | NH

スフィンゴ糖脂質 		Phosphosphingolipid
| OH
(C14-chain)＝／＼／ーO-(phosphate)
(fatty acid) ー | NH

スフィンゴリン脂質

Go to Sphingolipid search.


スフィンゴ脂質 Sphingolipid

Notation

分類体系 ID-Code Design

Major series of phosphosphingolipids are determined by molecules bound to their phosphates, and the series of glycosphingolipids are determined by oligosaccharides bound to their ceramides. The IUPAC series of glycosphingolipids (1977) were based on the order and bonding patterns of four sugars rooting at the long-chain base. Our series, however, are based on three sugars. Two original series, Echino and Schisto, are also added.

スフィンゴリン脂質はリン酸に結合する分子や糖の種類、スフィンゴ糖脂質はセラミドに結合する糖鎖により系列を作成しています。1977年にIUPACが提唱したスフィンゴ糖脂質の系列は、長鎖塩基に結合する四糖の並びと結合を基準にしています。ここではより広い糖鎖の系列を検索できるよう、三糖を基準に分類しています。また新たにEchinoとSchistoの系列を加えています。

L B S G/P s1 s2 n1 n2 y c1 c2
 
G/P G (glyco) P (phospho)
s1, s2 structure code as explained below
n1, n2 number of sugars (2 digits)
y number of sialic acids (1 digit)
c1, c2 serial numbers

スフィンゴ糖脂質 Glycosphingolipid

First sugar Code Root sequence Major Series
Cerebroside For GalCer and GlcCer, visit this page.
starting with
Galactose

(
) 		Gal-Cer
Galα1-4/6Galβ1-Cer
Galβ1-4Glcβ1-3Galβ1-Cer
starting with
Glucose

(
) 		GalNAcβ-Galβ-Glcβ-Cer
GalNAcβ1-4Galβ1-4Glcβ1-Cer
[1] 		GalNAcβ1-3Galβ1-4Glcβ1-Cer
GlcNAcβ1-3(GalNAcβ1-4)Galβ1-4Glcβ1-Cer
GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ1-Cer
GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ1-Cer
GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ1-Cer
...(NeuAcα2-6)GalNAcβ1-4Galβ1-4Glcβ1-Cer
...(NeuAcα2-8NeuAcα2-6)GalNAcβ1-4Galβ1-4Glcβ1-Cer

(
) 		GlcNAcβ-Galβ-Glcβ-Cer
Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ1-Cer
[2] 		Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer

(
) 		Galα-Galβ-Glcβ-Cer
Galα1-4Galβ1-4Glcβ1-Cer
[1] 		Galα1-3Galβ1-4Glcβ1-Cer

(
) 		Gal-Glc-Cer
(Other than G2∼G4)
Galβ1-4Galβ1-4Glcβ1-Cer

(
) 		Man-Glcβ-Cer
GlcNAcβ1-3Manβ1-4Glcβ1-Cer
Manα1-3Manβ1-4Glcβ1-Cer

(
) 		NeuAc/NeuGc-Glcβ-Cer
NeuGc or NeuAcα2-6Glcβ1-Cer

(
) 		GalNAc-Glc-Cer
[3] 		GalNAcβ1-4Glcβ1-Cer
starting with
Other Sugars
Symbols follow the Category:LBS#Sugar-Digit Table.
  1. ↑ 1.0 1.1 In IUPAC, "iso" refers to a change from position 4 to position 3.
  2. ↑ In IUPAC, "neo" refers to a change from position 3 to position 4.
  3. ↑ Makaaru CK, Damian RT, Smith DF, Cummings RD. "The human blood fluke Schistosoma mansoni synthesizes a novel type of glycosphingolipid" J Biol Chem 1992 267:2251-2257 PMID 1733932

スフィンゴリン脂質 Phosphosphingolipid

First sugar Code Root sequence Major Series
No Sugar Attached P1 (LBSP) R-P-Cer Sphingomyelin and Ceramide phosphoetanolamine
(Visit this page.)
starting with
Inositol

(29 items) 		GlcNα/β1−2/6Ins1-P-Cer
GlcNα/β1-2/6Ins1-P-Cer

(10 items) 		GlcAα/β1−2/6Ins1-P-Cer
GlcAα/β1-2/6Ins1-P-Cer

(52 items) 		Manα/β1−2/6Ins1-P-Cer
Manα/β1-2/6Ins1-P-Cer

(21 items) 		Gal, Glc, and Others X-Ins1-P-Cer

Sugar-Digit Table

Click to see the full list. For abbreviations, see #Notation.

Code Structure
A Glc LBS-Monomer-Glc.png
B Gal LBS-Monomer-Gal.png
C GlcNAc LBS-Monomer-GlcNAc.png
D GalNAc LBS-Monomer-GalNAc.png
E GlcN LBS-Monomer-GlcN.png
F GalN LBS-Monomer-GalN.png
G GlcA LBS-Monomer-GlcA.png
H GalA LBS-Monomer-GalA.png
I not used
Code Structure
J
LBS-Monomer-Man.png
K
LBS-Monomer-Rha.png
L
M Fucose (
,
,
) LBS-Monomer-Fuc.png
N
LBS-Monomer-Ara.png
O
LBS-Monomer-Xyl.png
P
LBS-Monomer-NeuAc.png
Q
LBS-Monomer-NeuGc.png
R
LBS-Monomer-KDN.png
Code Structure
S
LBS-Monomer-P.png
T
,
,
LBS-Monomer-AEPn.png
U
LBS-Monomer-S.png
V acyl/alkyl/alkenyl chain LBS-Monomer-Alkyl.png

Biosynthesis

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine on the ER membrane. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (trans-form) at the C-4 position (2-amino-4-octadecene-1,3-diol). (more details)

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)でトランス型の不飽和結合をC-4に1つ含みます。（詳細はこちら）


History of Sphingolipids

Sphingolipids were first isolated from brain by J.L.W. Thudichum (1829-1901) as lipids of unknown function and structure.[1] The basic structure is a long-chain base (long-chain amino-alcohol) whose amino-group is acylated with a long-chain fatty acid. This hydrophobic structure is called ceramides. Sphingolipid consists of phospho-sphingolipid and glyco-sphingolipid, whose ceramide structure is bonded with phosphate and (oligo)saccharides, respectively. Phosphosphingolipid includes sphingomyelin, and glycosphingolipid, cerebrosides and gangliosides. Both are abundant in neural tissues.[2]

スフィンゴ脂質は J.L.W. Thudichum (1829-1901) により機能や構造未知の脂質として脳から見いだされました。基本骨格は長鎖塩基 (長鎖アミノアルコール) のアミノ基が長鎖脂肪酸とアミド結合したもので、セラミドと呼ばれます。 スフィンゴ脂質はセラミドにリン酸が結合したスフィンゴリン脂質と糖が結合したスフィンゴ糖脂質に分けられます。スフィンゴリン脂質にはスフィンゴミエリンが、スフィンゴ糖脂質にはセレブロシドやガングリオシドなどが含まれ、いずれも神経系に多く存在します。

  1. ↑ Thudichum J.L.W.?"A Treatise on the Chemical Constitution of the Balliere" Tindall and Cox, London,?1884
  2. ↑ Gault CR,?Obeid LM,?Hannun YA "An overview of sphingolipid synthesis to breakdown" Adv Exp Med Biol.?2010;688:1-23. PMID 20919643


Subcategories

This category has the following 4 subcategories, out of 4 total.

L

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