LBF20406HO18
| LipidBank Top (トップ) |
Fatty acid (脂肪酸) |
Glycerolipid (グリセロ脂質) |
Sphingolipid (スフィンゴ脂質) |
Journals (雑誌一覧) |
How to edit (ページの書き方) |
| IDs and Links | |
|---|---|
| LipidBank | DFA8136 |
| LipidMaps | LMFA03060008 |
| CAS | |
| KEGG | {{{KEGG}}} |
| KNApSAcK | {{{KNApSAcK}}} |
| mol | LBF20406HO18 |
| 12R-Hydroxy- (5Z,8Z,10E,14Z) -eicosatetraenoic acid | |
|---|---|
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| Structural Information | |
| 12R-Hydroxy- (cis-5,cis-8,trans-10,cis-14) -eicosatetraenoic acid | |
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| 12(R)-HETE | |
| Formula | C20H32O3 |
| Exact Mass | 320.23514489 |
| Average Mass | 320.46628 |
| SMILES | C(CC=CCC(C=CC=CCC=CCCCC(O)=O)O)CCC |
| Physicochemical Information | |
| 12(R)-HETE is produced by the action of 12(R)-lipoxygenase on arachidonic acid Hawkins_DJ et al.. | |
| 12(R)-HETE is the predominant stereoisomer produced by psoriatic skin scales and rat liver microsomal cytochrome P-450 Woollard_PM Capdevila_J et al.. | |
| 12(R)-HETE is the primary lipoxygenase product in invertebrates such as the sea urchin where it plays a role in reproduction physiology Hawkins_DJ et al..1 12(R)-HETE has been isolated from several tissues in mammals, but it is controversial whether it is derived from cytochrome P450 or 12(R)-lipoxygenase metabolism, in some cases. 12(R)-HETE is a potent chemotactic factor exhibiting dose-dependent neutrophil chemotaxis with significant responses observed at doses as low as 10 ^{-11} M Masferrer_JL et al.. It produces neovascularization in rabbit corneas at 0.5 μg. | |
| Spectral Information | |
| Mass Spectra | |
| UV Spectra | λ max: 237nm ε : 27,000 |
| IR Spectra | |
| NMR Spectra | |
| Other Spectra | |
| Chromatograms | |
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